Boutique hotel vacation rentals in South Carolina

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in South Carolina

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Hotel room in Columbia

5 out of 5 average rating, 18 reviews

Trundle Double Queen

Wrap yourself in a plush robe and enjoy the luxury of a locally crafted Queen bed, hand-picked art, 100% cotton linens, and a taste of local Columbia from check-in, to breakfast. Complete with state-of-the-art technology, including Bluetooth enabled door locks, and control plus mirroring capabilities to 55" high definition TV's using your smart device. Our double queen rooms only reside within the Western Auto building yet share unique historic character, ranging from exposed structure and historic brick, to high round windows and the silhouette of stairs that once were. -Complimentary Local Draft Beer at Check-in -Evening Sip & Nibble reception with wine and a locally procured treat. -Complimentary Local Coffee, Local Baked Good, and Fruit from 6:30am-9:30am

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Hotel room in North Charleston

4.79 out of 5 average rating, 277 reviews

The Starlight Motor Inn - King + Pool!

The Starlight Motor Inn is a historic mid-century motel in the heart of N. Charleston, SC! Family run since 1961, The Starlight was conceived as an affordable and accessible destination for locals and visitors alike. In 2022 the property was lovingly restored & reimagined as a 51 room oasis conveniently located on Rivers Avenue just minutes from downtown Charleston. The property is complete with a fabulous pool, full service bar The Burgundy Lounge with nightly live entertainment, & event space!

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Hotel room in Charleston

4.91 out of 5 average rating, 163 reviews

INDIGO room at Pinckney

Welcome to the INDIGO room. This historic INN boasts 5 charming rooms with exterior access at the heart of the market and stables. Please click our bio photo to view all rooms, rates & reviews. You will enjoy a King bed, private bath, wifi, TV and a Fireplace in cooler months. Complimentary snacks, pastries and beverages. INDIGO is located on the second floor, you will need to climb stairs. We do not offer onsite parking but convenient parking lots are all within 1-2 blocks. $20-30 per night.

Hotel room in Charleston

4.76 out of 5 average rating, 54 reviews

The Patio Suite

Charming studio English Basement suite located in a fully renovated 1850's antebellum mansion. No detail was overlooked in the renovation of this historic home in Charleston's Cannonborough neighborhood, featuring beautifully restored cypress wall panelling, a custom-kitchenette with high-end finishes, French Baroque inspired-tin ceiling paneling, and exquitie bath finishes including reclaimed 1854 Vermont roofing slate from the house and a polished nickel British high-tank water closet.

Guest favorite

Hotel room in Myrtle Beach

5 out of 5 average rating, 8 reviews

Oceanfront Penthouse-Style Lux Condo w/ Amenities

It's like a country club in the sky! Enjoy a luxurious getaway in this oceanfront penthouse-style condo on the 14th floor of the Maisons Sur Mer building on Shore Dr. on the north end of Myrtle Beach. With views to the NE, E, S, & SW, you can enjoy sunrises + sunsets from your balconies overlooking the white Grand Strand beaches. Country club amenities w/ a gorgeous pool, putting green, fitness facility, tennis courts, dining. Sleeps 6 across 3 beds + 1-2 on couches, w/ 2 full bathrooms.

Guest favorite

Hotel room in Sellers

4.93 out of 5 average rating, 14 reviews

Magnolia Manor: Diamond Suite

Stunning first-floor room with a bay window and private en suite bathroom. Located just 10 minutes from I-95, 30 minutes from Florence, and 1 hour from Myrtle Beach, the Magnolia Manor is the perfect escape for a romantic getaway, the independent traveler seeking adventure, or the family looking for a place to rest on a long road trip (additional rooms available to rent). The fee includes access to the dining room, lounge, coffee bar, upper balcony, and partial access to the grounds.

Guest favorite

Hotel room in Murrells Inlet

4.96 out of 5 average rating, 114 reviews

The Inlet Cottage Guests Suite

You’ll love the stylish decor of this charming place to stay. Decorated with the ‘beach’ vibe. One block from the beautiful Murrells Inlet Marshwalk and Restaurants.This is a totally private area at the back of our home. You will have access to the pool, hot tub and private deck. There is a refrigerator in your room as well as a stocked coffee bar. There are other toiletries available if you forget anything. Bath and pool towels are in the room.

Guest favorite

Hotel room in Folly Beach

4.92 out of 5 average rating, 75 reviews

Boutique Hotel Folly Room 4: King Studio

The Studio room has a living area, kitchenette, and King size bed in the same room. There is a full bathroom. This studio room is on the third floor. Dog friendly with a one-time fee of $110 per dog up to 3 nights, and $150 per dog for 4 or more nights. Fee is added once your reservation is confirmed. PLEASE NOTE THE LOCATION OF THIS ROOM IS ON THE 3RD FLOOR AND IS IN THE MIX OF COMMERCIAL CENTER STREET ACTIVITY, YOU WILL HEAR THE NOISE

Hotel room in Folly Beach

4.64 out of 5 average rating, 25 reviews

Folliday Inn: The Torpedo: Room 22

Room 22- The Torpedo. This 2nd floor guest room has a private entry, a king bed, mini fridge, microwave, free WIFI, & smart TV for 2 guests. The bathroom is outfitted w/ a tub & shower. Swim in the largest pool on Folly Beach! 1 block from beach access. Great romantic escape! Must be 21 to book. 1 parking pass provided. NO smoking. 1 dog allowed w/ additional $125 + tax fee. Pool will be closed from Sept 3-8, 2024.

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Hotel room in Myrtle Beach

New place to stay

Luxury 1BR Signature Collection | Beach Access

Step into our 746 sq. ft. Luxury 1BR Signature Collection unit at Myrtle Beach Oceanfront Resort, where beachfront relaxation awaits just steps from your unit. Enjoy the perfect family getaway with kid-friendly splash pads, multiple outdoor pools, and poolside bars. With direct access to Myrtle Beach's top attractions and luxurious accommodations, it's the ideal escape for families and friends!

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Hotel room in Folly Beach

4.83 out of 5 average rating, 100 reviews

Beachside Boutique Inn - Shabby Chic Room

The Shabby Chic is in our Quirky cottage set, a favorite among longtime lover of the Beachside because you can cook in the cute kitchen, enjoy the deck area and tiki bar (no bartender but the liquor store is one block away), sit at the long table or chill on the little porch or lounge couch. Three private rented rooms each with it's own bathroom, open up to the shared ammentities.

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Hotel room in Charleston

4.69 out of 5 average rating, 309 reviews

Charleston's Most Charming Historic Inn

In the heart of Charleston’s charming historic district sits The Elliott House Inn, one of the most beloved historic Charleston properties. Featuring a cozy and quaint guestroom that opens to a delightful Charleston styled courtyard. This room features rich hardwood floors, an armoire, and all in room amenities.