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Guesthouse vacation rentals in South Carolina

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for South Carolina guesthouse rentals

Family-friendly guest house rentals

Guest favorite
A serene outdoor living space is observed, featuring a fenced in-ground pool surrounded by a paved patio. Comfortable seating is arranged near the pool, complemented by vibrant flowers in planters. A trampoline is visible in the background, set amidst lush greenery.
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 245 reviews

Studio Apt - (Pets/beach/pool/golf)

JoRating, 5 stars4 months ago
My husband and I were here for three nights with our dogs. My husband golfed and I was interested in wildlife so the location was fantastic - everything felt really close; the place is clean, comfortable and pet friendly, which was important for us. We’d definitely come back if we have a chance to visit Pawley’s island again!
Top guest favorite
A well-maintained lawn features a manicured, artificial turf area leading to a charming guest house. Surrounding greenery and a path of gravel create a welcoming entry. The guest house displays a simple entrance, framed by lush foliage, contributing to a private, tranquil setting.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 243 reviews

Bungalow Under The Oaks

JacquelineRating, 5 stars1 week ago
Everything was clean and perfect. Location was great, it’s easy to get to everything. Pete & Jessica were easy to communicate with and left outside lights on because of our late arrival.
Top guest favorite
Two classic cars are parked in front of a detached garage, showcasing a vintage white convertible and a sleek gray vehicle. The garage features two closed doors, framed by light green siding and surrounded by trees, adding to the serene environment.
Guesthouse in Summerville
4.88 out of 5 average rating, 795 reviews

New Loft in Historic Summerville

BrandenRating, 5 stars5 days ago
Jacquelynn is a very responsive and helpful host and everything about the loft was great. The check in and out instructions were clear and easy to follow. The Loft itself was clean and all the amenities were easy to find.
Guest favorite
A serene bedroom features a spacious bed with a white coverlet and decorative pillows. Natural light enters through a window, illuminating a bedside lamp and a small table. A dresser complements the decor, while artwork adds a touch of color to the muted green walls.
Guesthouse in North Charleston
4.93 out of 5 average rating, 394 reviews

Cozy Park Circle, Charleston Guest House

CaitlynRating, 5 stars4 weeks ago
Very convenient place to Park Circle and the major highways in Charleston.
Top guest favorite
A comfortable living area is presented with a mix of seating options, including a couch and two armchairs. Natural light enters through the windows, which are dressed in soft curtains. A coffee table sits in the center, complemented by tasteful decor on the walls.
Guesthouse in Donalds
4.99 out of 5 average rating, 370 reviews

Home on the farm

TaraRating, 5 stars3 weeks ago
We didn’t get to fully enjoy it, due to other obligations. Our kids loved it and want to come back to stay for week. :) Mrs. Ruth and Mr. Robert were so kind, friendly and helpful. Such a peaceful place to stay. Highly recommend!
Superhost
A charming yellow cottage is framed by lush greenery, with a cozy seating area featuring bright blue chairs. A colorful hammock hangs nearby, creating an inviting space for relaxation. Sliding glass doors lead into the cottage, promoting a cheerful and welcoming atmosphere.
Guesthouse in Charleston
4.84 out of 5 average rating, 117 reviews

Romantic Beach Style Cottage close to everything!

DanielRating, 5 stars6 months ago
If you’re looking for a unique place to stay, that’s well situated between the beach and downtown, this is a great option. Anything this place lacks in square footage, it makes up for in character, charm and overall vibe. October mornings with the outdoor shower are not for the faint of heart, but I wouldn’t have it any other way. My wife loved the decor, outdoor lighting, plants in the shower, windows looking out to green-spaces. The bed is super comfy and cozy. Kokomo is awesome, we want to check out Roatan.
Guest favorite
The open loft features a spacious bed and a striped couch adorned with decorative pillows. Natural light floods through large windows that frame views of the surrounding woods. Natural wood floors and a small side table complete the cozy atmosphere.
Guesthouse in Salem
4.89 out of 5 average rating, 307 reviews

Mountain Edge Loft

JewelRating, 5 stars3 months ago
Beautiful land and home, cute dogs and chickens, the bread was delicious and i definitely recommend California's Mexican Grill, it was yummy!! The fire pit was so warm. Everything was clean and comfortable, Marsha responded to our messages in a short time and was very kind, will recommend to friends!
Guest favorite
A charming log cabin is nestled among lush greenery, featuring wooden walls and a sloping roof. The front door is framed by two windows adorned with flower boxes. Two white chairs sit on a stone pathway, inviting relaxation in the serene outdoor setting.
Guesthouse in Greenville
4.92 out of 5 average rating, 661 reviews

Historic 19th Century Cabin/Guest House

MelisaRating, 5 stars4 days ago
Tony was welcoming and accommodating. One reviewer mentioned traffic noise, and while the cabin does sit next to a busy thoroughfare, I didn’t find the noise too disturbing. Overall, worth the price for the convenient location, private parking, and full kitchen. Bonus: Very close to the Swamp Rabbit Trail—we were dropped off at the Ingle’s grocery on Geer Highway and rode to the cabin to from the trail. Approximately 22 miles.

Guest house rentals with a patio

Guest favorite
An outdoor lounge area features a spacious sectional sofa in dark upholstery, surrounding a low wooden coffee table. Potted plants add greenery around the space. A shed with blue siding and double glass doors sits in the background, framed by tall trees and a wooden fence.
Guesthouse in Charleston
4.94 out of 5 average rating, 236 reviews

Quaint Cottage Studio in Ashley Forest (Avondale), New Zealand

JenniferRating, 5 stars6 days ago
John and his family offer a cozy place to rest after exploring the nearby neighborhoods by foot and the region by car. A comfy bed, a responsive host, a central location and great local recommendations were highlights.
Top guest favorite
Guesthouse in Campobello
4.97 out of 5 average rating, 115 reviews

Bungalow on a 3 acre mini farm

BrandiRating, 5 stars1 week ago
Wow—what a gem of a stay! Jonathan is one of the kindest and most thoughtful hosts we’ve ever had. We loved the fresh eggs and getting to hear how he got into hosting—it really added a personal and meaningful touch to our visit. The place itself felt like a page straight out of a storybook—cozy, charming, and full of little details that made it feel magical. There was so much to do, from fun games to quiet spots to relax. The tub was incredibly relaxing—exactly what we needed after a long day of hiking. Total bliss! We’re already planning to try out the fire pit next time too. And don’t worry about going hungry—Jonathan provides so much food. You definitely won’t starve here! Thank you again, Jonathan, for such a wonderful and memorable stay. Can’t wait to come back!
Guest favorite
A vibrant rainbow appears against a backdrop of lush green trees, with a serene lake visible in the distance. The colors of the rainbow contrast harmoniously with the surrounding foliage, creating a peaceful natural scene.
Guesthouse in Batesburg-Leesville
5 out of 5 average rating, 8 reviews

Beautiful Lake Front 1 bedroom Guest House

TracyRating, 5 stars6 months ago
Rhonda was always willing to help with anything I needed. During Hurricane Helen we lost power and water. Rhonda traveled to North Carolina and picked up a generator to take care of us. Rhonda is willing to go the extra mile to ensure her guests have a great stay in her guests house. I will definitely stay there again.
Superhost
A cottage exterior is shown, featuring a covered patio with three colorful chairs in green, blue, and yellow. The front door is framed by greenery and a decorative lamp, creating a welcoming entry. A gated area is visible alongside the house.
Guesthouse in Myrtle Beach
5 out of 5 average rating, 10 reviews

Cozy 1 Bdrm Cottage~ 1mi to beach~Sleeps4

CarissaRating, 5 stars3 months ago
Very nice and cozy cottage. The bed was very comfortable! We loved that we could bring our dog and that it was fenced in! They were very accommodating and let us stay a little past check out so we could spend more time with our family.
Top guest favorite
The interior features a cozy living area with a dark gray sectional sofa, complemented by decorative pillows. A circular coffee table sits in front, holding a tray with books and a remote. The kitchen appears in the background, showcasing a modern design with white cabinetry.
Guesthouse in Inman
4.99 out of 5 average rating, 118 reviews

Foothills Favorite

Melanie And JasonRating, 5 stars2 weeks ago
Phyllis's over-garage apartment suite is quiet, well-appointed, comfortable and clean. Phyllis is a wonderful host - kind and proactive. All instructions were clear. The space is modern and spotless - new TV's with guest accounts; rain shower; new appliances; comfortable bed and pillows. Phyllis clearly spared no expense in putting the space together. It is in a somewhat rural area - so private, safe and you can see the stars at night. But, perfectly located to access all things Spartanburg or Greenville in 20-25 minutes. Highly recommend Phyllis's place and will not hesitate to stay there again.
Top guest favorite
A light-filled living area features a comfortable sectional sofa and a ceiling fan. Two windows provide natural light, while a TV is mounted on the wall. A decorative painting adds color above the sofa, and a woven area rug lies underfoot.
Guesthouse in Johns Island
4.96 out of 5 average rating, 113 reviews

Driftwood Cottage

RobertRating, 5 stars5 days ago
Terry’s place was even nicer than the photos. It was extremely clean with helpful instructions listed on the sideboard, even told us where to find the hair dryer (which I usually have to search for). The bed was very comfortable and the place was very quiet, so thankful to get a good nights sleep. Terry greeted us and asked if there was anything we needed. He was very friendly and thanked us for staying with him. We would love to stay there again.
Guest favorite
A shaded outdoor seating area is furnished with a comfortable couch and chairs, surrounded by tropical plants. A flat-screen TV is mounted on the wall, while a dining table awaits nearby. The entrance door adds a touch of charm to the inviting space.
Guesthouse in North Charleston
4.92 out of 5 average rating, 130 reviews

My Happy Place

HeidiRating, 5 stars1 week ago
Great place to stay at. had a amazing outdoor area and pool if only it was warm enough to have enjoyed it. there even was a TV outside but it was to chilly for us to sit out there. she had a heater if we needed it. super cute spot to stay and not far from downtown. Highly recommend
Top guest favorite
A well-maintained outdoor pool is surrounded by a concrete patio, featuring a railing and steps for easy access. Lush greenery and landscaping provide a natural backdrop, with a shed visible in the distance. Outdoor seating is arranged nearby for relaxation.
Guesthouse in Greenville
4.97 out of 5 average rating, 129 reviews

Finished Room over Garage (FROG) on Reedy River

JuanitaRating, 5 stars1 week ago
It was so beautiful and peaceful A beautiful view to drink your morning Coffee So quiet no traffic sounds Very very clean Couch and bed very comfortable I really enjoyed the trail great walk I loved everything Bret was a great host Always quick to answer questions Checked to see if we needed anything So friendly I would stay again It was such a great stay😄😄😄😄😄😊

Guest house rentals with a washer and dryer

Superhost
A modern living area features a sleek black sectional sofa with orange accent pillows. Large windows provide natural light and views of the patio. A wall-mounted TV and two armchairs complement the spacious, airy environment.
Guesthouse in Travelers Rest
4.78 out of 5 average rating, 18 reviews

Quiet King Two Bedrm House

CherieRating, 5 stars1 month ago
It was a nice space for a weekend at Furman. Close to downtown Travelers Rest. They have done a nice job renovated an older home. They were quick to answer any question. We had all our needs met. The backyard has a lot more potential, but it also looks like they have to clear some damage from the hurricane.
Top guest favorite
A detached two-car garage is visible, featuring brown doors and white siding. Above the garage, a cozy guest house is present, capped with a pitched roof and adorned with multiple windows. Lush greenery surrounds the structure, enhancing the outdoor space.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 146 reviews

Groves Carriage House, near Shem Creek

JimiRating, 5 stars5 days ago
Wonderful, responsive hosts. This above garage unit has everything you need. The neighborhood is very accessible to anywhere you want to go. 5 minutes from Shem Creek. 15 minutes to Sullivan’s Island or Isles of Palms. Roughly 10-15 minutes from Downtown Charleston. The hosts were very helpful with any of my simple needs. I would definitely stay here again.
Top guest favorite
Guesthouse in Beaufort
4.98 out of 5 average rating, 406 reviews

The Wren Guest House

BerkleyRating, 5 stars3 days ago
Absolutely charming! Would definitely come back and recommend to others! Had everything we needed! Beaufort is a hidden gem and The Wren was perfect! Thank you! 😍 Berkley and Martha Gray
Top guest favorite
A scenic view captures a dock extending over calm waters, surrounded by lush greenery. The setting sun casts a warm glow, enhancing the tranquil scene. Boats are visible at the dock, with trees providing a natural frame to this picturesque moment.
Guesthouse in Bluffton
4.96 out of 5 average rating, 357 reviews

Old Town Bluffton Carriage Apt.

WilliamRating, 5 stars2 weeks ago
Was a great experience, a beautiful place with every amenity. Really appreciated the attention to detail, had everything you could want in a vacation type rental. Well thought out place, plenty of info available in binders and posts. Not a big traveller but you're sure on top of my list for a return visit to the area. Thanks!
Top guest favorite
A charming cabin features rustic wooden exteriors accented by bear carvings on two outdoor chairs. In front, a stone fire pit is surrounded by fallen leaves, with a warm fire flickering inside. Soft lights adorn the covered porch, enhancing the cozy ambiance.
Guesthouse in Westminster
4.99 out of 5 average rating, 169 reviews

Lit'l Bit O' Heaven- Rocky Top Lodge

SharonRating, 5 stars2 weeks ago
Absolutely loved this little cabin. Very comfortable and would definitely stay again.
Top guest favorite
A modern kitchen features stainless steel appliances, including a refrigerator and a gas range. Light-colored cabinetry contrasts with dark countertops. A large kitchen sink is complemented by a stylish faucet. Natural light enters through a window adorned with white blinds, enhancing the space's functionality.
Guesthouse in Bluffton
4.98 out of 5 average rating, 130 reviews

Carriage House at 12 Lawrence

KathyRating, 5 stars2 weeks ago
We enjoyed our stay at Kristin and Tyler’s bungalow very much! The location was perfect for our nephew’s wedding in Old Town Bluffton, and the bungalow was clean, nicely decorated, and well equipped. We would definitely stay again if in the area, and highly recommend it to others!
Top guest favorite
A serene courtyard area is surrounded by lush greenery, featuring two wooden lounge chairs and a small table. Flower pots add vibrant touches, while a trellis structure enhances the space. The light-colored paving stones provide a welcoming path for guests.
Guesthouse in Charleston
4.99 out of 5 average rating, 292 reviews

Spacious Daniel Island Apartment

JohnRating, 5 stars1 month ago
We had a great stay on Daniel Island. The neighborhood is quiet and attractive with miles of walking or biking paths. Beautiful pond 1 block away. The apartment is clean and bright, bed was super comfortable. Be prepared for a fairly long flight of stairs going up. The Charleston area has many great historical attractions plus many nice restaurants. We would recommend David and Shirlie’s place to anyone!
Guest favorite
An outdoor patio area is featured, featuring wooden decking and a central fire pit. Two lounge chairs and a circular table provide a comfortable gathering spot. Surrounding greenery and a brick wall contribute to a serene atmosphere, with dappled sunlight casting soft shadows.
Guesthouse in Charleston
4.96 out of 5 average rating, 166 reviews

Charleston Casita near Folly Beach *Dog Friendly*

AndrewRating, 5 stars1 week ago
Loved staying in the casita! Great if you have pets with a huge yard for them to play. Great location if you want to explore Charleston!

Destinations to explore