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House vacation rentals in Cape Girardeau

Find and book unique houses on Airbnb

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Popular amenities for Cape Girardeau house rentals

House rentals with a hot tub

Top guest favorite
The exterior of the vacation home is surrounded by a spacious yard with fallen leaves, revealing a fire pit nearby. A porch with wooden railings offers elevated views of the surrounding trees and landscape. The western-facing aspect allows for natural light and scenic vistas.
Home in Carbondale
4.98 out of 5 average rating, 63 reviews

Hot Tub Overlooking Sunset Ridge | Sleeps 6

ErinRating, 5 stars2 weeks ago
We had a great time for a short time away for our spring break. We had hiking planned In local state parks and also took a trip to Garden of the gods. The hot tub was a nice way to relax after a day away. We enjoyed having a fire and was helpful to have firewood available to use. We saw tons of stars and heard many owls. It was peaceful and a very quiet setting. The house was clean and we loved that it was pet friendly as well. Check it was easy and Allison checked in frequently. Also bonus to have washer and dryer in the home as well. Thank you!
Superhost
Home in Cape Girardeau
4.4 out of 5 average rating, 5 reviews

Large Home, 2 King Beds, HotTub, Air Hockey, Games

BrandenRating, 5 stars3 weeks ago
We had a team of 9 for a week and the place had everything we needed! Abbie was a responsive host and the location was fantastic. Memories to be made and non stop conversation starters. One of the most fun air bnbs that I’ve been a part of over the years. Thank you!
Superhost
The charming exterior of a two-story home is surrounded by lush greenery and landscaping. A welcoming front porch features multiple seating areas and flower pots, while the well-maintained walkway leads to the entrance. A small garden and decorative flag add to the inviting atmosphere.
Home in Cape Girardeau
4.72 out of 5 average rating, 230 reviews

3+ acre:King Bed, Hot Tub, Mini Golf, Pool Table

PatrickRating, 5 stars1 month ago
Cute place. Very comfortable for our family of four. Perfect home base for our adventures. Great communication. Would stay again.
Guest favorite
A hot tub is situated on a deck, surrounded by a white railing overlooking a scenic view of trees. An umbrella provides shade for an adjacent outdoor seating area, creating a peaceful retreat. The water's surface has gentle ripples, reflecting the soft blue sky.
Home in Cobden
4.97 out of 5 average rating, 67 reviews

Wine trail cozy cabin! Hot Tub!

JessicaRating, 5 stars2 weeks ago
The location was truly fantastic, offering a wonderful sense of privacy. We especially enjoyed the comfortable bed and the excellent hot tub. The only area for improvement would be the couch, which unfortunately wasn't as comfortable as the rest of the accommodations.
Top guest favorite
A two-story cabin is set against a wooded backdrop, featuring a large covered porch and a stone landscaping feature at the foreground. An American flag is displayed proudly from the upper balcony, hinting at a welcoming atmosphere.
Home in Alto Pass
4.95 out of 5 average rating, 59 reviews

Alto Cabin-1/2 mile from 3 wineries!

SusanRating, 5 stars1 week ago
We LOVE Alto Cabin! Gorgeous scenery and very relaxing. The house is ADORABLE with something for everyone! Wrap around porch, game area for the kids, and an idyllic back patio, campfire seating all beautifully landscaped and decorated inside and out! We enjoyed yoga on the deck, a dip in the hot tub and games at the table (with plenty of seating for gamers which was a big reason I picked Alto Cabin). We each had our own rooms AND bathrooms which was another WIN! Saw some wildlife in the forest including deer and maybe even Big Foot?! LOVED IT!!! Thank you to our hosts for sharing this little slice of heaven!
Top guest favorite
A charming Victorian house showcases a well-maintained exterior with a turret and decorative trim. A vibrant garden featuring a variety of flowers, including marigolds and petunias, surrounds a pathway leading to the entrance. A pumpkin and decorative elements add seasonal touches to the inviting landscape.
Home in Cobden
4.95 out of 5 average rating, 21 reviews

Peacock On Poplar

RachelRating, 5 stars1 week ago
Friends and I had a great stay. Beautiful old home that is nicely updated. We used Wrightway travel to get a shuttle to wineries, and this was a great home base. Would stay here again. A couple quirks to keep in mind while you’re planning your trip: there’s no real TV room. So, if your group intends to watch something as a group, keep that in mind. No full oven but does have a nice countertop air fryer. Lots of plates, glassware, and kitchen and condiment basics are included. The hot tub was nice! Also, we ate brunch at The Iron Whisk nearby and really enjoyed our food!
Top guest favorite
A spacious sleeping area features a large bed with a dark blue coverlet and two matching pillows. Two bedside lamps are placed on wooden nightstands. A textured area rug adds a touch of comfort, and natural light enters through a nearby window dressed with dark curtains.
Home in Cobden
4.97 out of 5 average rating, 32 reviews

The King's Quarters

BretRating, 5 stars2 weeks ago
This place is Perfectly located., whether you are looking for wineries or you are simply a nature lover. You are only minutes away from Giant City, Anna, and Carbondale. The true bonus is the hotub in back. ☆☆☆☆☆ Thank you Kim and we hope to be back.

Weekly house rentals

Guest favorite
A charming cottage is framed by tall trees, with a paved walkway leading to the front door. The yellow exterior of the home contrasts with the greenery. Fallen leaves scatter across the grass, creating a serene and inviting visual.
Home in Anna
4.94 out of 5 average rating, 35 reviews

150 year old charmer!

JaniceRating, 5 stars1 week ago
This is the second time I stayed in this particular location. The first time wasn't an anomaly. Awesome stay. You can tell Monty takes pride in his location.
Top guest favorite
A stately two-story farmhouse with a wrap-around porch is shown, featuring white siding and multiple large windows. A pair of yellow chairs is positioned on the porch, inviting relaxation. The roofline features a distinctive, curved gable, enhancing the home's classic design.
Home in Carbondale
4.99 out of 5 average rating, 81 reviews

Mulberry Hill Farm

RickRating, 5 stars5 months ago
We had another great stay with Tom and Kelley at Mulberry Farms in Carbondale, IL. The big farm house is fantastic as are the grounds and scenery. The house is wonderfully furnished and equipped with everything we needed. We spend every evening sitting around the campfire. The best part of our stay was the friendliness of our hosts. Tom and Kelley treated us like family, and made us feel very welcome. We have stayed there before, and we always look forward to seeing them. They are genuinely good people.
Top guest favorite
An outdoor fire pit is surrounded by seating, with string lights overhead creating a warm ambiance. A cozy bedroom features a spacious bed with bright orange and grey accents, and large windows allow for natural light. A well-equipped kitchen has modern appliances, complemented by a welcoming sign.
Home in Cobden
4.96 out of 5 average rating, 73 reviews

Winery on Property and directly on Wine Trail

DorrisRating, 5 stars1 month ago
A group of us (7 people) came for an event that was happening nearby and we all really enjoyed our stay. There was plenty of room for all of us. Michelle was flexible regarding an early check-in and responded in a timely manner with any inquiries we had. The Airbnb being next to the Honey Heist Mead Co was an added plus. We talked about accommodation for next year's event and we agreed to stay at this AirBnb again if it's available!
Superhost
The exterior of the home features a single-story structure with a neutral-colored façade and a welcoming front porch. A large window provides ample natural light, while neatly trimmed shrubs and greenery frame the entrance. A curved walkway leads to the front door.
Home in Cape Girardeau
5 out of 5 average rating, 3 reviews

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!

LottieRating, 5 stars5 days ago
Cape Charm is an excellent place to stay! The owners were very kind and helpful while we were there. The house was spotless and in a great location for us. We were in town for SEMO baseball and we could easily walk to the park.
Top guest favorite
A spacious kitchen features modern white cabinetry and a large central island, enhancing the food preparation area. Stainless steel appliances are positioned strategically, providing a sleek look. Natural light fills the room through large windows, while a neutral colour palette maintains a welcoming atmosphere.
Home in Perryville
5 out of 5 average rating, 22 reviews

German-Inspired Home in Perryville

RobertRating, 5 stars1 month ago
Excellent as always
Guest favorite
A charming brick home features a welcoming front porch adorned with colorful flower pots and a variety of plants. A stone pathway leads to the entrance, and vibrant seating is arranged on the porch, providing an inviting outdoor space.
Home in Cape Girardeau
4.88 out of 5 average rating, 72 reviews

Downtown Home steps away from Food and Fun

HelamanRating, 5 stars2 weeks ago
Danah and Robert’s place was really nice and quiet. We enjoyed staying at their place. I highly recommend.
Guest favorite
A single-story home is framed by large trees, featuring a well-maintained lawn. A carport stands adjacent to the entrance, providing shaded parking. The brick facade complements the light siding, and a small bicycle is casually positioned nearby.
Home in Murphysboro
5 out of 5 average rating, 17 reviews

Cozy 3 bedroom/1 bath home in Murphysboro IL

Abdulaziz Al AnoohiRating, 5 stars4 months ago
Andrew’s place was unexpectedly an amazing place to stay at, loved everything there. With 3 bedrooms having 2 bathrooms instead of 1 would help a lot, as for the garage having a remote to open it would be less hassle than entering the house going inside the garage opening it from inside then get in the car take it inside. Other than that the place is amazing and very well organized, have the garage makes it safe and secure, sadly stayed short time .. Next time I come back again will definitely try to stay a bit longer days, definitely 💯 advise anybody who wants to rent an Airbnb nearby this spot, this place is amazing, secure & feel like in home and more .. much appreciated and thanks to Andrew & his crew 🙏🏻💐
Top guest favorite
A single-story house is surrounded by lush greenery, featuring large trees and a well-manicured lawn. The home is painted in a light blue hue, with a welcoming front porch that is accented by seasonal decor.
Home in Murphysboro
4.94 out of 5 average rating, 36 reviews

My Blue Heaven

AmyRating, 5 stars5 days ago
We enjoyed our second visit to Tracy’s place. Plenty of room for our family to enjoy a visit with our SIU student. Tracy was flexible with our checkout since we had a late flight back home which was greatly appreciated. We will be back!

Private house rentals

A serene sunrise is captured behind silhouetted trees, with soft rays of light filtering through the fog. A mailbox is positioned in the foreground, adding context to the tranquil rural scene.
Home in Murphysboro
4.71 out of 5 average rating, 156 reviews

2 Bedroom country craftsman

BarbRating, 5 stars3 weeks ago
This was a great spot for us! We were not at the house but to sleep and it met our needs perfectly. Michael has taken on a restoration of this beautiful home and done a fabulous job!
The living room features a spacious sectional sofa and a coffee table, complemented by an area rug with vibrant patterns. Natural light enters through large windows, with decorative curtains enhancing the space. A television and side table are positioned for functionality and comfort.
Home in Cape Girardeau
4.76 out of 5 average rating, 17 reviews

3 Bedroom home

PamelaRating, 5 stars18 months ago
Lovely house with the comfiest couch and great beds! Close to downtown but in a quiet little section, it was exactly what we wanted while staying a few days in town.
Guest favorite
The entrance features a wooden staircase leading to the upper floor, set against a backdrop of light-colored walls. Natural light illuminates the adjacent living space, furnished with a piano and a rocking chair. A decorative area rug adds warmth to the entryway.
Home in Cape Girardeau
4.86 out of 5 average rating, 65 reviews

Brickyard: Remodeled 1920's Dutch Colonial Revival

ScottRating, 5 stars2 months ago
Great weekend trip to the Cape for a track meet at SEMO. Chip was a great host and the house was very lovely. We will definitely stay here the next time we are in town for track.
Guest favorite
A two-story home is showcased at night, featuring a gabled roof and green shutters. The porch is adorned with white chairs and a bench, illuminated by moonlight. Lush greenery surrounds the property, contributing to a calming evening scene.
Home in Altenburg
5 out of 5 average rating, 11 reviews

Gem in Heart of Altenburg

LauraRating, 5 stars2 weeks ago
beds are comfy, bathrooms were spacious and clean, cozy home and ample parking
Guest favorite
The spacious living room features a grand piano, a plush seating arrangement, and an elegant coffee table. Natural light enters through large windows, illuminating the hardwood floors and decorative area rug. A standing lamp adds ambient lighting, enhancing the inviting atmosphere.
Home in Murphysboro
5 out of 5 average rating, 11 reviews

The SHAWNEE LEGEND

ColeRating, 5 stars4 months ago
Great place in Murphsboro Illinois. Perfect for our family group. Lots of room!
A comfortable living area is shown, featuring a gray sectional sofa with cozy throw blankets. A floor lamp provides soft illumination, while shelves hold various books and decorative items. A light-colored area rug is positioned on a wood-style floor, adding warmth to the space.
Home in Cape Girardeau
4.87 out of 5 average rating, 23 reviews

Cape Girardeau non-smoking lodging on quiet street

BreonnaRating, 5 stars37 months ago
I stayed here on an extended stay for 2 months. Charles and his wife were absolutely a gift from above. Being a solo first time traveler was new for me, but this place helped me feel like I was at home. They were responsive with everything that I needed. The place was also fully stocked with everything that I may have needed, even extra things that I didn’t think that I needed (trash bags, sandwich bags, paper towels, crock pot, various food seasonings, COFFEE :) etc.) You will be very lucky if you are able to book this place, it’s truly a treat. It’s also close to everything like the mall, Walmart, various places to eat, downtown, literally everything. The balcony is also a cool place to hang out. I’d definitely stay here again.
Top guest favorite
A comfortable living area is highlighted by a dark sofa and an ottoman, positioned on a patterned rug. Large windows allow natural light to fill the space, while a decorative wall art piece adds a subtle touch. A doorway leads to an adjacent bedroom.
Home in Murphysboro
4.88 out of 5 average rating, 273 reviews

3bed home w/ 2 car garage. Peaceful setting!

WalterRating, 5 stars3 months ago
Jessica's place is exactly as advertised. The house is clean and the surroundings are beautiful and peaceful. I have stayed with Jessica many times and will continue to do so. Jessica's place is a must stay and ranked at top of my list.
The exterior of the cozy tiny home is shown, featuring a light-colored facade and a small front porch with seating. Sunlight shines brightly, highlighting the grassy yard and surrounding trees. Stone steps lead from the porch to the yard.
Home in Perryville
4.78 out of 5 average rating, 9 reviews

'The Brewer Guesthouse' Tiny Home w/ Patio & Yard!

ChristineRating, 5 stars3 weeks ago
Quiet place and nice space to use! Very peaceful

Quick stats about house rentals in Cape Girardeau

  • Total rentals

    70 properties

  • Nightly prices starting at

    $30 before taxes and fees

  • Total number of reviews

    3K reviews

  • Family-friendly rentals

    40 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with dedicated workspaces

    40 properties have a dedicated workspace

Destinations to explore