
House vacation rentals in Cape Girardeau
Find and book unique houses on Airbnb
Top-rated house rentals in Cape Girardeau
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Cape Girardeau house rentals
House rentals with a hot tub

Hot Tub Overlooking Sunset Ridge | Sleeps 6
We had a great time for a short time away for our spring break. We had hiking planned In local state parks and also took a trip to Garden of the gods. The hot tub was a nice way to relax after a day away. We enjoyed having a fire and was helpful to have firewood available to use. We saw tons of stars and heard many owls. It was peaceful and a very quiet setting. The house was clean and we loved that it was pet friendly as well. Check it was easy and Allison checked in frequently. Also bonus to have washer and dryer in the home as well. Thank you!

Large Home, 2 King Beds, HotTub, Air Hockey, Games
We had a team of 9 for a week and the place had everything we needed! Abbie was a responsive host and the location was fantastic. Memories to be made and non stop conversation starters. One of the most fun air bnbs that I’ve been a part of over the years. Thank you!

3+ acre:King Bed, Hot Tub, Mini Golf, Pool Table
Cute place. Very comfortable for our family of four. Perfect home base for our adventures. Great communication. Would stay again.

Wine trail cozy cabin! Hot Tub!
The location was truly fantastic, offering a wonderful sense of privacy. We especially enjoyed the comfortable bed and the excellent hot tub. The only area for improvement would be the couch, which unfortunately wasn't as comfortable as the rest of the accommodations.

Alto Cabin-1/2 mile from 3 wineries!
We LOVE Alto Cabin! Gorgeous scenery and very relaxing. The house is ADORABLE with something for everyone! Wrap around porch, game area for the kids, and an idyllic back patio, campfire seating all beautifully landscaped and decorated inside and out! We enjoyed yoga on the deck, a dip in the hot tub and games at the table (with plenty of seating for gamers which was a big reason I picked Alto Cabin). We each had our own rooms AND bathrooms which was another WIN! Saw some wildlife in the forest including deer and maybe even Big Foot?! LOVED IT!!! Thank you to our hosts for sharing this little slice of heaven!

Peacock On Poplar
Friends and I had a great stay. Beautiful old home that is nicely updated. We used Wrightway travel to get a shuttle to wineries, and this was a great home base. Would stay here again. A couple quirks to keep in mind while you’re planning your trip: there’s no real TV room. So, if your group intends to watch something as a group, keep that in mind. No full oven but does have a nice countertop air fryer. Lots of plates, glassware, and kitchen and condiment basics are included. The hot tub was nice! Also, we ate brunch at The Iron Whisk nearby and really enjoyed our food!

The King's Quarters
This place is Perfectly located., whether you are looking for wineries or you are simply a nature lover. You are only minutes away from Giant City, Anna, and Carbondale. The true bonus is the hotub in back. ☆☆☆☆☆ Thank you Kim and we hope to be back.
Weekly house rentals

150 year old charmer!
This is the second time I stayed in this particular location. The first time wasn't an anomaly. Awesome stay. You can tell Monty takes pride in his location.

Mulberry Hill Farm
We had another great stay with Tom and Kelley at Mulberry Farms in Carbondale, IL. The big farm house is fantastic as are the grounds and scenery. The house is wonderfully furnished and equipped with everything we needed. We spend every evening sitting around the campfire. The best part of our stay was the friendliness of our hosts. Tom and Kelley treated us like family, and made us feel very welcome. We have stayed there before, and we always look forward to seeing them. They are genuinely good people.

Winery on Property and directly on Wine Trail
A group of us (7 people) came for an event that was happening nearby and we all really enjoyed our stay. There was plenty of room for all of us. Michelle was flexible regarding an early check-in and responded in a timely manner with any inquiries we had. The Airbnb being next to the Honey Heist Mead Co was an added plus. We talked about accommodation for next year's event and we agreed to stay at this AirBnb again if it's available!

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!
Cape Charm is an excellent place to stay! The owners were very kind and helpful while we were there. The house was spotless and in a great location for us. We were in town for SEMO baseball and we could easily walk to the park.

German-Inspired Home in Perryville
Excellent as always

Downtown Home steps away from Food and Fun
Danah and Robert’s place was really nice and quiet. We enjoyed staying at their place. I highly recommend.

Cozy 3 bedroom/1 bath home in Murphysboro IL
Andrew’s place was unexpectedly an amazing place to stay at, loved everything there. With 3 bedrooms having 2 bathrooms instead of 1 would help a lot, as for the garage having a remote to open it would be less hassle than entering the house going inside the garage opening it from inside then get in the car take it inside. Other than that the place is amazing and very well organized, have the garage makes it safe and secure, sadly stayed short time .. Next time I come back again will definitely try to stay a bit longer days, definitely 💯 advise anybody who wants to rent an Airbnb nearby this spot, this place is amazing, secure & feel like in home and more .. much appreciated and thanks to Andrew & his crew 🙏🏻💐

My Blue Heaven
We enjoyed our second visit to Tracy’s place. Plenty of room for our family to enjoy a visit with our SIU student. Tracy was flexible with our checkout since we had a late flight back home which was greatly appreciated. We will be back!
Private house rentals

2 Bedroom country craftsman
This was a great spot for us! We were not at the house but to sleep and it met our needs perfectly. Michael has taken on a restoration of this beautiful home and done a fabulous job!

3 Bedroom home
Lovely house with the comfiest couch and great beds! Close to downtown but in a quiet little section, it was exactly what we wanted while staying a few days in town.

Brickyard: Remodeled 1920's Dutch Colonial Revival
Great weekend trip to the Cape for a track meet at SEMO. Chip was a great host and the house was very lovely. We will definitely stay here the next time we are in town for track.

Gem in Heart of Altenburg
beds are comfy, bathrooms were spacious and clean, cozy home and ample parking

The SHAWNEE LEGEND
Great place in Murphsboro Illinois. Perfect for our family group. Lots of room!

Cape Girardeau non-smoking lodging on quiet street
I stayed here on an extended stay for 2 months. Charles and his wife were absolutely a gift from above. Being a solo first time traveler was new for me, but this place helped me feel like I was at home. They were responsive with everything that I needed. The place was also fully stocked with everything that I may have needed, even extra things that I didn’t think that I needed (trash bags, sandwich bags, paper towels, crock pot, various food seasonings, COFFEE :) etc.) You will be very lucky if you are able to book this place, it’s truly a treat. It’s also close to everything like the mall, Walmart, various places to eat, downtown, literally everything. The balcony is also a cool place to hang out. I’d definitely stay here again.

3bed home w/ 2 car garage. Peaceful setting!
Jessica's place is exactly as advertised. The house is clean and the surroundings are beautiful and peaceful. I have stayed with Jessica many times and will continue to do so. Jessica's place is a must stay and ranked at top of my list.

'The Brewer Guesthouse' Tiny Home w/ Patio & Yard!
Quiet place and nice space to use! Very peaceful
Quick stats about house rentals in Cape Girardeau
Total rentals
70 properties
Nightly prices starting at
$30 before taxes and fees
Total number of reviews
3K reviews
Family-friendly rentals
40 properties are a good fit for families
Pet-friendly rentals
20 properties allow pets
Rentals with dedicated workspaces
40 properties have a dedicated workspace
Destinations to explore
- St. Louis Vacation rentals
- Paducah Vacation rentals
- Shawnee National Forest Vacation rentals
- Carbondale Vacation rentals
- Murray Vacation rentals
- Ste. Genevieve Vacation rentals
- Meramec River Vacation rentals
- Belleville Vacation rentals
- Paris Vacation rentals
- Lake of Egypt Vacation rentals
- Marion Vacation rentals
- Nashville Vacation rentals
- Pet-friendly rentals Cape Girardeau
- Rentals with a patio Cape Girardeau
- Rentals with a washer and dryer Cape Girardeau
- Rentals with a fire pit Cape Girardeau
- Cabin rentals Cape Girardeau
- Apartment rentals Cape Girardeau
- Rentals with a fireplace Cape Girardeau
- Kid-friendly rentals Cape Girardeau
- Rentals with outdoor seating Cape Girardeau
- House rentals Missouri
- House rentals United States
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes