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Vacation rentals in Cape Girardeau

Book unique vacation rentals, houses, and more on Airbnb

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Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Minglewood Brewery13 locals recommend
Port Cape13 locals recommend
Katy O'Ferrell's Publick House9 locals recommend
Top of the Marq8 locals recommend
Isle of Capri Casino8 locals recommend
Coin-Op Cantina7 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favorite
Cabin in Jackson
4.93 out of 5 average rating, 30 reviews

The Cabin at Timber Creek

JakeRating, 5 stars2 weeks ago
I'm feeling like I should keep this gem to myself. What a find. perfect spot. great up to date look and feel. lots of comfortable furniture. bed was amazing, couch could fit 10 people. love this place.
Guest favorite
Place to stay in Murphysboro
4.93 out of 5 average rating, 46 reviews

4Bdrm~EACHw/PRIVATEBathrms!

Shetara LatriceRating, 5 stars4 months ago
I hosted a slumber party for my 10 year old and 9 of her friends, THEY HAD AN ABSOLUTE BALL!! The second night, my husband, mother and 3 children enjoyed a night ourselves, and no one wanted to leave the next morning! Thank you for providing such a comforting atmosphere for my family and I to enjoy!
Top guest favorite
Home in Cobden
5 out of 5 average rating, 41 reviews

South Pass Hideaway

DixieRating, 5 stars1 week ago
Absolutely perfect for a girls’ weekend! The space was amazing and had everything we needed for a relaxing getaway. We loved sipping wine, laughing around the table, and soaking in the peaceful vibe. The location was convenient but still felt like a retreat. Highly recommend for a fun, memory-making weekend with your favorite people!
Top guest favorite
Cabin in Makanda
4.98 out of 5 average rating, 116 reviews

Hygge Log Cabin: HotTub & Hiking

TylerRating, 5 stars1 week ago
This place was exactly what I was looking for — somewhere private to unwind. The location was secluded but still close enough to other amenities and activities. Jess was the perfect host and clearly communicated all information about the property before our arrival. She checked on us during our stay and reached out afterwards as well.
Guest favorite
Cabin in Dongola
4.95 out of 5 average rating, 37 reviews

HotTub! FirePit, Private Pond, GameRoom! Slps12+

AlyssaRating, 5 stars3 weeks ago
We enjoyed exploring the many beautiful parks in the region, relaxing on the huge deck, playing pool in the game room, cooking together in the large kitchen, kayaking, frisbee golf practice, and hiking the property. We had a great stay with no issues and made family memories at this beautiful house. The house is set up well for visitors (e.g., light switches labeled) and has all the amenities one would expect when booking an Air BnB. Thanks for hosting, Mark!
Top guest favorite
Cabin in Carbondale
5 out of 5 average rating, 23 reviews

Cabin on hobby farm.

JenniferRating, 5 stars3 days ago
My son and I very much enjoyed our stay. Both Jill and Danny were very responsive to any of our questions, and we really loved the trail that we were able to access for our private use. The animals were so much fun to be around.
Top guest favorite
Cottage in Burfordville
5 out of 5 average rating, 58 reviews

Entire Cottage Nestled in the Woods

KarenRating, 5 stars3 months ago
My family and I have stayed at Lara's place the last few years, and we absolutely love it! There is no clutter but plenty of seating and lots of space to stretch and move about. The location is private and perfectly close to our family in Jackson. Everything is always clean and inviting. Perfect home away from home!
Top guest favorite
Guesthouse in Jackson
5 out of 5 average rating, 39 reviews

Guesthouse w/ pool, outdoor fireplace, game room

OliviaRating, 5 stars1 month ago
Wynnette was truly an outstanding host! The entire place was spotless and had all we needed and more! The cinnamon rolls were such a kind gesture, too. Overall we were blown away by the cleanliness and coziness. 😍

Quick stats about vacation rentals in Cape Girardeau

  • Total rentals

    150 properties

  • Nightly prices starting at

    $20 before taxes and fees

  • Total number of reviews

    9.1K reviews

  • Family-friendly rentals

    70 properties are a good fit for families

  • Pet-friendly rentals

    40 properties allow pets

  • Rentals with dedicated workspaces

    80 properties have a dedicated workspace

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Cape Girardeau?

    Yes! Work meets play with ease at over 80 vacation rentals in Cape Girardeau featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Cape Girardeau?

    Four-legged friends are welcome in Cape Girardeau. Choose from more than 40 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Cape Girardeau?

    Experience the best of Cape Girardeau with our house rentals, starting at about $30 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Cape Girardeau have self check-in?

    Absolutely! We offer over 20 house rentals with self check-in in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Cape Girardeau have wifi?

    Absolutely! We offer over 60 house rentals with wifi in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly house rentals in Cape Girardeau?

    Cape Girardeau has more than 40 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

Destinations to explore