Guesthouse vacation rentals in Charleston County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Charleston County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

A bright living area features a deep blue sofa with decorative pillows, facing a mounted television. A charming dining set with pink chairs and a round table sits adjacent to the fully equipped kitchen, where stainless steel appliances complement white cabinetry.

Guesthouse in Mount Pleasant

4.93 out of 5 average rating, 112 reviews

Old Village Guest House - 5 Mins to the Beach!

Discover the ultimate Charleston experience in the heart of Mount Pleasant's charming Old Village! Immerse yourself in the vibrant energy of this renovated, adorable guest house. Nestled close to pristine beaches, restaurants, and the storied streets of historic Charleston, this Airbnb is your gateway to a quintessential Lowcountry adventure. Don't just visit Charleston—live it, love it and make unforgettable memories at this delightful retreat! $3500/mo. MP Permit - ST240210 MP BL – 20123265

Top guest favorite

A spacious yard is surrounded by tall trees and lush greenery, creating a serene atmosphere. Sunlight filters through the foliage, casting gentle shadows onto the manicured grass. A small structure is visible in the distance, blending harmoniously with the natural surroundings.

Guesthouse in Charleston

5 out of 5 average rating, 171 reviews

The Guesthouse at Old Orchard

Relax in the treetops of our beautiful pecan grove! Guests adore the peaceful surroundings of our new 1260 sq ft guesthouse located on the second floor of a detached garage. This private space has an open floor plan, fully stocked kitchen, 2 queen bedrooms, 2 full baths, wifi, Roku TVs, and new appliances including washer and dryer. Sitting on 1.3 acres, the property is home to gardens, a tidal creek, and happy hens! It is quiet yet centrally located between downtown Charleston and Folly Beach.

Top guest favorite

An open loft space features wooden beams and a high ceiling, illuminated by warm lights. A cozy seating area with a wooden sofa overlooks a rustic dining and kitchen area. A bed with patterned linens is positioned to the right, creating a welcoming atmosphere.

Guesthouse in Summerville

4.98 out of 5 average rating, 696 reviews

★Delightful guest house near historic plantations★

Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*

Guest favorite

The exterior of a rustic wooden guest suite is shown, nestled among greenery and trees. A stairway leads to a small porch, while a circular trampoline is positioned in the yard. Natural pathways of stones create an inviting entrance to the building.

Guesthouse in Charleston

4.91 out of 5 average rating, 196 reviews

Riverland Terrace Guesthouse

Private and quiet guest suite perfect for nature lovers. Our guest house is tucked up against a small marshy area in our backyard on James Island. Located about 5 minutes to downtown Charleston, 5 minutes to John's Island and 15 minutes to Folly Beach. Five minute walk to the Pour House and all terrace area restaurants and the terrace theater. We are a very laid back couple looking for laid back guests who need a quiet and peaceful place to use as their base while exploring Charleston.

Top guest favorite

The living area is arranged with a spacious sectional sofa adorned with colorful pillows. A wooden coffee table sits in the center, complemented by a light rug. Natural light filters through the windows, illuminating the space and highlighting the rustic wooden beam above.

Guesthouse in Charleston

5 out of 5 average rating, 104 reviews

Liz Lane Cottage- entire guesthouse

Our brand new guest house is a spacious one bedroom, one bath with a bunk loft. Come enjoy our quiet neighborhood after a full day of sightseeing. Located 2 miles from downtown, 10 miles from Folly beach or Sullivan’s island, this tastefully decorated guest house will not disappoint! Guests will have access to the entire cottage. The backyard is shared with the main house.This quaint West Ashley neighborhood is seated in between downtown and the trendy shops of Avondale. STR permit #04191

Guest favorite

A modern two-story guest house is depicted, featuring a combination of white and light brown exteriors. A covered entryway with pergola extends over the front door. A tranquil pool is visible in the foreground, surrounded by landscaped greenery and stone paving.

Guesthouse in Mount Pleasant

4.96 out of 5 average rating, 122 reviews

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

LOCATION, LOCATION, LOCATION! Welcome to Persimmon Place, a brand new guesthouse in the heart of Old Village in Mt. Pleasant. Historic Old Village is one of Charleston's most beautiful neighborhoods, central to all Charleston has to offer. This 2BR 1 BA is the perfect spot for your Lowcountry visit. -Walk to Shem Creek with bars, restaurants, & water activities -Less than 4 miles(8 min drive)to Sullivan's Island Beach -5 miles(9 min drive)to downtown Charleston ST240164 BL20127902

Top guest favorite

A narrow wooden pathway leads through a fenced area, bordered by neatly arranged plants and subtle lighting. A charming guesthouse is visible at the end, with windows reflecting the ambient light of the surroundings.

Guesthouse in Charleston

4.96 out of 5 average rating, 281 reviews

Urban Oasis, West of the Ashley

Private, renovated guesthouse in a quiet neighborhood. Studio includes everything needed for a short or long stay, including a kitchen with a stove and microwave for cooking, seating area to relax, and beautiful deck to enjoy the outdoors. Separate entryway and fenced in area for ultimate privacy. Convenient to all the charm Charleston offers, including: 5 miles to downtown, biking distance to great restaurants and bars, 12 miles to Folly Beach and 14 miles to Sullivan's Island.

Top guest favorite

A well-maintained lawn features a manicured, artificial turf area leading to a charming guest house. Surrounding greenery and a path of gravel create a welcoming entry. The guest house displays a simple entrance, framed by lush foliage, contributing to a private, tranquil setting.

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 243 reviews

Bungalow Under The Oaks

Small guest house in the heart of Mount Pleasant! Ideally located to both Isle of Palms and Sullivan's Island beaches (both 7 minutes) and only 15 minutes to the heart of historic downtown Charleston. Our private guest bungalow is a perfect launching spot for all your exploring. End the day relaxing under the shade of our mature live oak. The house has its own entrance and separate yard that is fully fenced in. LHR Permit: ZSTR-02-21-00318, License: LIC-3-21-252314.

Top guest favorite

A cozy outdoor seating area features a circular fire pit surrounded by built-in wooden benches. Soft cushions are placed for comfort. String lights are hung above, illuminating the space. Potted plants and greenery add a touch of nature to the welcoming atmosphere.

Guesthouse in Charleston

4.98 out of 5 average rating, 172 reviews

Private Backyard With Fire Pit, 15 Min to Downtown

Welcome to this newly renovated guesthouse in the heart of West Ashley. While staying in this adorable 850 sqft. home, you'll fall in love with the newly redone kitchen featuring a cozy breakfast nook. You'll also enjoy: Deck with outdoor table & chairs Free Laundry Smart TVs in all rooms Fully stocked and equipped kitchen Extremely safe neighborhood Free Parking You are only: 10 mins to Avondale 15 mins to Downtown Charleston 30 mins to Folly Beach

Top guest favorite

A well-appointed kitchen is highlighted by light cabinetry and a marble countertop. Stainless steel appliances, including a refrigerator and a gas stove, complement the space. A small dining area is set with two stools at the countertop, while natural light filters through the window.

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 458 reviews

Guesthouse Convenient to Charleston, Shem Creek, and Beaches

Relax in this separate guest home nestled in a well-established Lowcountry neighborhood. The ‘treehouse’ has an open-plan design with vaulted notched board ceilings, creating a feeling of light and space, with elegant furnishings throughout. The well-equipped kitchen and grill on the porch encourages intimate home cooking. We lived in this space before we moved into the main house, so we can attest to it being comfortable, and well maintained.

Top guest favorite

A welcoming driveway leads to a two-story home, framed by illuminated lanterns at the entry. Lush greenery and a white picket fence enhance the serene setting, while the evening light casts a warm glow along the pathway.

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 246 reviews

Charleston Guesthouse

Conveniently nestled in the heart of Mt. Pleasant and only a short car ride from the best that Charleston has to offer including beaches and down town. Minutes away from historic sites such as Boone Hall Plantation, Palmetto Island County Park, Belle Hall shopping center and many other attractions. Located in a quiet community reminiscent of old country living. Sit back and enjoy the peacefulness of your home away from home.

Top guest favorite

The image depicts a wooden dock extending into calm waters, with gentle ripples reflecting blue skies and scattered clouds. Lush greenery and trees line the banks, offering a peaceful natural setting. A warning sign is mounted on a post near the dock's entrance.

Guesthouse in Hanahan

4.99 out of 5 average rating, 182 reviews

The Violet Villa w/no cleaning fee

Come enjoy this beautiful private guesthouse conveniently located minutes from shopping, food, venues and the beach. When you arrive, we have cooled bottled water to quench your thirst. As the evening sets, stroll the nature trail and catch the sunset from the neighborhood dock. A 70” smart tv awaits your return so you can watch your favorite movies (without sharing an armrest). Come relax! This is a vacation for you

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What guests are saying

Peaceful Garden Cottage Retreat

5 out of 5 average rating, 119 reviews1 month ago

The cottage was a great place to stay and unwind after a busy day of sightseeing. It's in a quite neighborhood outside of the busy historic district, but close enough to easily uber and avoid parking challenges. The cottage is comfortably furnished and stocked with basics as well as some unexpected frills (cookies, wine, beverages). Those added extras were very thoughtful!

Guesthouse in Charleston

What guests are saying

Boho Converted Garage Apt. - Cozy & Convenient!

4.93 out of 5 average rating, 816 reviews1 week ago

Great stay and great location! You’re within a short walk to lots of different eateries! The place itself is comfy and cozy and great if you’re wanting to explore all of Charleston without staying in the hustle and bustle of everything!

Guesthouse in North Charleston

What guests are saying

Indigo House Poolside Retreat

4.93 out of 5 average rating, 399 reviews2 weeks ago

We loved our stay at the Indigo House! It was clean, nicely decorated and comfy for the two of us. It included all of the amenities we needed including beach chairs and a cooler to use. It was a perfect location between downtown Charleston and Folly beach. We’ll definitely stay here again on our next trip.

Guesthouse in Charleston

What guests are saying

Creekside Cottage (Tiny Home)

4.93 out of 5 average rating, 299 reviews2 weeks ago

Stayed (from FL) for our 10 yr anniversary and had an absolute blast. Perfect middle point between Folly Beach and downtown Charleston. Never had been and she and Russel gave us so many recommendations. We stayed 3 days but felt there was so much more to see and do. Place was perfect, tiny....but was exactly what we needed.

Guesthouse in Charleston

What guests are saying

Ocean Inspired Village Hideaway Old MP

4.99 out of 5 average rating, 351 reviews2 weeks ago

I had an amazing stay! The location was SUPER convenient to get to Sullivan's Island and Charleston. The private drive right in front of the unit was a nice plus. Loved walking to Pitt Street and biking over to Sullivan's Island. Sissy was proactive and responsive with communication......and really friendly! I felt right at home and will definitely look here first for availability when I stay in Mount Pleasant. Really,...it was more than I had hoped for. Thank you!

Guesthouse in Mount Pleasant

What guests are saying

Old Mt. Pleasant/Shem Creek close to Sullivans/DT

4.97 out of 5 average rating, 511 reviews2 weeks ago

The accommodations where great. We had everything we needed and the place was decorated and planned out so well. Jeremy was easy to communicate with and very responsive. Great quiet family oriented neighborhood conveniently located near restaurants, shops and nearby towns.

Guesthouse in Mount Pleasant

What guests are saying

Casa Del Sol - Adorable Guest house in Park Circle

4.73 out of 5 average rating, 64 reviews1 week ago

We really enjoyed our stay. We traveled to downtown, Magnolia Plantation, Folly Beach and many other restaurants/coffee shops. This was easy access on/off the highway and convenient. Everything was clean and cozy. Also, Jason was very understanding about letting us have our son come visit for 1 night during our stay. I highly recommend!

Guesthouse in North Charleston

What guests are saying

NEW Coastal Retreat in the Heart of Mount Pleasant

5 out of 5 average rating, 7 reviews2 weeks ago

Michelle was one of the best hosts my wife and I ever had throughout our travels. Her space was clean, beautifully decorated, easy to access and was absolutely perfect for our vacation in Charleston. The location is also unbeatable - minutes away from Sullivan’s Island and downtown Charleston. Not to mention, Mount Pleasant itself is beautiful. We would stay again in a heartbeat!

Guesthouse in Mount Pleasant

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