Sikeston places to stay

Book unique places to stay, houses, and more on Airbnb

Top-rated places to stay in Sikeston

Guests agree: these places to stay are highly rated for location, cleanliness, and more.

Guest favorite

Cabin in Alto Pass

4.99 out of 5 average rating, 259 reviews

Ma's Cabin, Alto Pass, IL. Fine country lodging.

Cute and country remodel done in 2019. Recent new appliances, furnishings, flooring, heat & A/C, washer & dryer. Cabin is secluded and quiet plus 1/2 mile from Alto Pass Lookout Point and right in the middle of many award-winning wineries. 15 miles from Carbondale 4 miles from Giant City 30 miles from Garden of the Gods 6 lakes within 10-mile radius Hundreds of miles of hiking trails in nearby Shawnee National Forest 6 miles from Bald Knob Cross Please, no dogs! No smoking in cabin!

Guest favorite

Treehouse in Greenville

5 out of 5 average rating, 231 reviews

Secluded couple's treehouse "The Roost" + hot tub

"The Roost" is rustic but not primitive treehouse 2 hrs south of St Louis near Wappapello Lake. Yes it has indoor plumbing & running water. Accommodates two adults, has a fully equipped kitchen and breakfast items are provided for you to cook. Surrounded by thousands of acres of national forest. Observe wildlife sightings from the deck while soaking in the hot tub, sleep comfortably in a queen size pillowtop Serta bed on a Motion Air base, and relax as you enjoy the ambience of the fireplace.

Guest favorite

Guest suite in Cape Girardeau

4.97 out of 5 average rating, 137 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Superhost

Loft in Cape Girardeau

4.92 out of 5 average rating, 105 reviews

Riverwalk Loft 1

If you are looking for something right in the middle of the excitement, book now! This is your place. Our lofts are right in the heart of Downtown. In walking distance to breweries, casinos, and shopping galore.Our building is directly in front of the Mississippi River entrance. Walk around the corner either to get an ice cream for a late night snack. Beds are super comfortable but downtown isn’t the quiet part of town. The train runs periodically. You will have the typical night life noise.

Guest favorite

Home in Cape Girardeau

4.84 out of 5 average rating, 110 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guest favorite

Cottage in Cape Girardeau

4.98 out of 5 average rating, 353 reviews

The Candle Cottage in downtown Cape.

All the best that downtown Cape Girardeau has to offer just steps away from your front door! Short distance from Isle Casino and just 2 1/2 blocks from the Mississippi River walk, downtown restaurants, shops and minutes from Southeast Missouri State River Campus. Completely renovated with loads of charm and coziness, high ceilings, comfy bed, fully stocked kitchen, and laundry. My place is ideal for couples, solo adventurers, and business travelers. Owner is licensed real estate agent.

Guest favorite

Apartment in Cape Girardeau

4.98 out of 5 average rating, 126 reviews

Downtown Penthouse w/ Amazing River View!

AMAZING RIVERVIEW Plus Close to Downtown Cape? Our Airbnb is the best place to be! Relax in our Roof Deck after going around downtown and ENJOY THE VIEW. Located in a safe and quiet neighborhood plus it is WALKING DISTANCE from everything! It features a roof deck with (by far) the best view in Cape, enough space for six to sleep (two queen beds and two couches), one off street parking spot and a building with secure entry. Plus we just live across the street if you need anything.

Guest favorite

Home in Piggott

5 out of 5 average rating, 22 reviews

The Little Zebra Cottage

Your family will be close to everything when you stay at this centrally-located place. Accessible from both Main Street as well as two side streets, the side driveway can accommodate multiple cars or recreational vehicles. The address is walkable to restaurants, groceries, school facilities, and even church establishments. Local festivities, family events, and museums often draw visitors to this quaint town and our AirBnb provides the perfect place to rest at the end of a long day.

Guest favorite

Farm stay in Arcadia

4.92 out of 5 average rating, 131 reviews

Alpaca Farm Stay (save 10% for non-refundable)

Come see the baby alpacas and stay at the most tranquil and private getaway retreat in Arcadia Valley, Missouri and reconnect with nature. Our alpaca farm is nestled on over 28 acres in the Saint Francois Mountains next to the Mark Twain Natl Forest. The lodge is the perfect place for fishing on our 4-acre lake, relaxing after a long day of hiking, and meeting a small herd of alpaca. Your group will have an opportunity for a one-hour meet-and-greet scheduled at your convenience.

Guest favorite

Home in Alto Pass

4.99 out of 5 average rating, 115 reviews

The Farmhouse in Rhine Valley

Newly renovated Farmhouse in Alto Pass situated between Trail of Tears State Forest and just a hike or short drive away from Bald Knob Cross and wilderness. Minutes away from local wineries. Enjoy a peaceful pause from the hustle and bustle in our private little Farmhouse. Perfect for single family or small groups. Nearby venues and activities include: hiking, fishing, public hunting, wineries, restaurants, and many other local venues and events. Hunters are welcome.

Guest favorite

Tiny home in Marion

4.97 out of 5 average rating, 234 reviews

Tiny House Cabin near Lake Egypt, Hiking, Wineries

Our charming cabin offers an ideal retreat for a romantic couple's escape or a memorable family outing. Thoughtfully designed, the 565-square-foot living space embodies the essence of a quintessential southern Illinois experience. With its pet-friendly policy and convenient proximity to the Lake of Egypt, hiking trails, and wineries, it promises an all-encompassing getaway. The swimmable pond is stocked with bass and bluegill with a few catfish and Koi.

Guest favorite

Farm stay in Fredericktown

4.93 out of 5 average rating, 319 reviews

NEW DC Farmhouse Come relax in our HOT JACUZZI

Peaceful & Cozy Farm Life Great place to relax and enjoy country living. You can sit outside on covered deck, by the fire pit, or in the hot tub while watching horses and cattle graze. We also have a t.v and DVD player with a few dvds or you can bring your own to wind down and relax and watch a movie.