Some info has been automatically translated. Show original language

Panacea vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

0 of 0 items showing
1 of 3 pages

Popular amenities for Panacea vacation rentals

Stay near Panacea's top sights

Gulf Specimen Marine Lab & Aquarium42 locals recommend
Posey's Up the Creek Steam Room15 locals recommend
The Seineyard Rock Landing15 locals recommend
Dollar General7 locals recommend
My-Way Seafood7 locals recommend
Mineral Springs Seafood By The Bay6 locals recommend

Panacea beach vacation rentals

Guest favorite
The exterior of the beach home is showcased, featuring a light-colored facade with ample windows. The home is elevated on stilts, surrounded by landscaped grass and various plants. A set of steps leads up to the front entrance, with a clear blue sky in the background.
Home in Alligator Point
4.96 out of 5 average rating, 77 reviews

*Beach House w TIKI BAR*

JillRating, 5 stars1 month ago
Great house! Easy walk to public beach access.
Guest favorite
A serene view of the beach and ocean is presented, showcasing gentle waves lapping against the shore. Sandy dunes and patches of greenery are visible in the foreground, while two nearby houses frame the scene against a clear blue sky.
Home in Saint George Island
4.96 out of 5 average rating, 26 reviews

April 26 - May 3 is ON SALE! 1st Tier-Private Pool

PaulRating, 5 stars11 months ago
One level. Split masters, beach path as shown. Always stayed in the Plantation, pleasantly surprised with close proximity to everything.
Top guest favorite
Townhouse in Port St. Joe
4.97 out of 5 average rating, 30 reviews

Oceanfront | 2 Balconies | BONUS $150/day | Dog-Fr

FernandaRating, 5 stars3 weeks ago
The Airbnb was nice, clean and organized with a great view of the ocean. My kids loved the arcade games and had so much fun at the beach. We loved watching the sunrise and sunset from the balcony. We enjoyed the easy access to the beach. Alexandra was so responsive and gave us some nice recommendations around the area.
Guest favorite
An aerial view of a contemporary home with a teal roof, situated on pilings amid a coastal landscape. Nearby structures with varied colors contribute to the laid-back island atmosphere. The Gulf of Mexico is visible in the distance, framed by a clear blue sky.
Home in Saint George Island
4.82 out of 5 average rating, 230 reviews

100 STEPS TO THE GULF-CONTEMPORARY-SOARING CEILING

PhilipRating, 5 stars2 weeks ago
Our family had a great time at Molcie's. The location is very conveniently located near the beach. It takes no time at all to get there by foot, even while carrying beach chairs and pulling a wagon. The place was as described and checking in/out was a breeze. I love that she allowed us to bring our fur babies for an extremely fairly priced dog fee. We will be back!
Guest favorite
The exterior of a two-story house showcases a blend of light and dark siding, framed by a gravel driveway and landscaped greenery. A welcoming porch with railing and ceiling fans is visible, along with windows allowing natural light to enter the home.
Home in Saint Teresa
5 out of 5 average rating, 12 reviews

Family Tree

LoriRating, 5 stars9 months ago
Beautiful home. We loved all the marine life we were able to find. The only complaints we had was there wasn’t a grill and the pool not being in the neighborhood. Overall a great week. Would definitely recommend.
Guest favorite
A sandy beach is filled with a variety of seashells, reflecting muted tones in the soft light of sunset. Gentle waves can be seen lapping at the shore, complementing the serene atmosphere created by the distant horizon.
Condo in Saint George Island
4.9 out of 5 average rating, 131 reviews

Walk to Beach & Attractions! Remodeled & Spacious

SaraRating, 5 stars1 week ago
Ruth is a wonderful host, very responsive, kind and helpful with any questions you have about Saint George. It’s a beautiful place especially if you are looking to be in walking distance of restaurants, shopping, and other family attractions. The rentals are walking distance too. It is above a Subway, which I didn’t mind and neither did my kids that were down there everyday we were there. Lol! The management there was very nice upon arrival letting us know if there was anything we needed to let them know which was very kind. It’s very quiet at night. We enjoyed our stay and recommend.
Top guest favorite
A two-story house is depicted with a light purple exterior and large screened porches on the upper level. The surrounding yard contains grass and small shrubs, with stepping stones leading towards the entrance.
Home in Eastpoint
4.98 out of 5 average rating, 56 reviews

CR Beach

JayneRating, 5 stars8 months ago
We had a wonderful family vacation on St. George Island. The kitchen and common areas were great. We were able to have meals together, play games, and watch the Olympics. We had the beach to ourselves! The pool was right out the back door!
Guest favorite
A covered deck features a round table surrounded by four metal chairs, providing a comfortable space for outdoor dining. A serene view of lush greenery is visible in the background, with a wooden floor that enhances the inviting atmosphere.
Condo in Crawfordville
4.93 out of 5 average rating, 85 reviews

Shell Point Beach 2BR condo | Balcony views

ErinRating, 5 stars1 month ago
It was a lovely place.

House rentals in Panacea

Superhost
The exterior of the home features a light brown stucco façade complemented by a brick accent on the garage. A single-car garage is visible, accompanied by a manicured lawn and bordered flower beds. Large windows allow natural light to fill the inviting entryway.
Home in Tallahassee
4.91 out of 5 average rating, 106 reviews

Beautiful home with room for the entire family!

OliviaRating, 5 stars3 weeks ago
This was a nice home for my family to visit FSU for my upcoming Freshman. Neighborhood was very quiet and clean. Very close to the school than I expected. Home had everything you need with little to nothing to add during your stay. Definitely first in an Airbnb home to have everything available from towels to remove makeup to spices to make your favorite meal along with bakeware and dishes. Would recommend and will consider staying here again when visiting my daughter in school.
Top guest favorite
A modern living area features dark leather seating arranged around a silver coffee table. A ceiling fan provides airflow above, while a large TV mounted on the wall displays a scenic sunset. A dining area with grey barstools is visible in the background.
Home in Tallahassee
4.98 out of 5 average rating, 218 reviews

Intimate 3/3 by FSU, FAMU, & downtown Tallahassee

KariRating, 5 stars3 weeks ago
We were in town for a wedding, the home was welcoming, within walking distance of the venue, very clean with a pretty backyard. If we were to come to the area again we would definitely rebook.
Superhost
A single-story house is framed by lush green trees and a well-maintained lawn. The home features a bright yellow front door, and a driveway leads to the garage. Fencing is visible in the backyard area, promoting privacy.
Home in Tallahassee
4.86 out of 5 average rating, 470 reviews

My House, Your House

LaRhondaRating, 5 stars2 weeks ago
SPECIAL Thanks to JENN! I am deployed to Tallahassee for work and Jenns's place made me feel comfortable, safe at home, and relaxed after a 10hr work day. The home is just as pictured. My furbaby enjoyed the private fenced backyard. And there's a safe walking path right across the street; which I loved! Jenn"s communication is TOP notch. She's very responsive and accommodating. I have already rebooked. THANK YOU JENN!
Guest favorite
A charming home is set amidst lush greenery, featuring a front porch with a wooden railing. The exterior is accented by a sloped roof and large windows, allowing for natural light. A well-maintained lawn complements the inviting atmosphere.
Home in Tallahassee
4.86 out of 5 average rating, 230 reviews

Quiet Cul de sac;1mile I-10;6 miles FSU; 6.5 FAMU.

SarahRating, 5 stars2 days ago
Great price for the money, particular for dog owners. Henry was very responsive even on a holiday weekend. Plenty of space, comfortable, quiet safe neighborhood, good internet speeds. Loved being close to FSU for our student. Starting to show wear due to consistent rentals but overall great.
Superhost
A spacious outdoor area is shown, featuring a newly constructed home in the background. A wooden fence encloses the property, providing privacy. Ample parking space is available in front of the house, which is accented by a clear blue sky and lush trees in the vicinity.
Home in Tallahassee
4.71 out of 5 average rating, 14 reviews

Brand NEW House-.5Mi to FSU/1.6Mi to FAMU

NickRating, 5 stars1 week ago
Very happy with my stay here! The nightly rate is a great value considering the location and everything provided in the house. Ameer and Tacorra answered messages quickly and seem like awesome people. Ameer and the house definitely exceeded expectations.
Superhost
A welcoming living area features two gray sofas adorned with green accent pillows, positioned around a round wooden coffee table. Natural light filters through sheer curtains, illuminating the hardwood floors. A potted plant adds a touch of greenery to the space.
Home in Tallahassee
4.83 out of 5 average rating, 200 reviews

3 Bedroom Trendy Elegant Vibe close to Colleges

LarryRating, 5 stars3 weeks ago
Stayed the weekend for a soccer tournament. A very short 2 minute commute to our soccer fields. Great house, very cozy and comfortable. All kids had their own beds and weren’t climbing into ours. We had a great weekend and loved our stay.
Top guest favorite
The outdoor area features a sprawling green lawn surrounded by manicured bushes and palm trees. Tall trees provide shade, creating a tranquil atmosphere. Sunlight filters through the leaves, highlighting the natural beauty of the space, ideal for outdoor activities.
Home in Crawfordville
5 out of 5 average rating, 22 reviews

Tranquility Meets Convenience

EdwardRating, 5 stars3 weeks ago
Our crew of four had a comfortable stay. There is plenty of space and they want me to reserve it again as we have work in the area.
Superhost
A bright foyer features light-colored hardwood flooring and an open staircase leading to the upper levels. Double doors on the left open to additional rooms, while a window allows natural light to illuminate the space.
Home in Tallahassee
4.89 out of 5 average rating, 9 reviews

Modern Luxury House with Prime Time Convenience

AnnieRating, 5 stars17 months ago
We had the pleasure of staying at Anthony's Airbnb home in Tallahassee during our company's team offsite. Despite a minor address mix-up (quickly resolved by the host), the house matched the pictures exactly. Its location was within walking distance of the downtown core, Saturday Farmer's Market, and Cascades Park. It spans three floors and has two staircases. There are no carpet runners, which is something to consider for anyone traveling with young children or older family members. Although we didn't use the hot tub, the host had thoughtfully removed its cover. I recommend this clean, modern & conveniently located home for anyone visiting Tallahassee.

Beach house rentals in Panacea

Top guest favorite
A spacious deck with wooden flooring provides a view of the surrounding landscape, including homes and greenery. A comfortable seating area is present, enhancing the outdoor experience. The space is framed by black railings, offering a welcoming ambiance for relaxation.
Home in Panacea
5 out of 5 average rating, 24 reviews

Face in the Wind

AmyRating, 5 stars3 months ago
The house was in near new condition and very well appointed with everything needed and more. The location is a short walk to beach access and is located on the bike/walk path. Our group loves the area and Patrick's place was perfect and super clean. Patrick was a great communicator and we appreciated that so much. I highly recommend to other guests.
Top guest favorite
A spacious living area is filled with comfortable seating, including two light-colored sofas and a wicker chair. Large windows allow natural light to fill the room, highlighting a decorative wall piece and a flat-screen television. A soft rug anchors the space, enhancing its inviting feel.
Home in Saint Teresa
4.94 out of 5 average rating, 18 reviews

Pure Bliss

KaylaRating, 5 stars3 days ago
Shelbey’s place was beautiful. The beach was so calm and perfect for the little kids to play in. It was the perfect place for a relaxing vacation. Any time we had a question Shelbey was very quick to respond and she was very accommodating. We will definitely be coming back!
Top guest favorite
A serene beachfront scene captures soft, white sand bordered by gently lapping waves. Tall trees provide a natural backdrop, interspersed with quaint homes nestled amongst the greenery. The tranquil environment invites relaxation, accentuated by the natural sounds of the ocean.
Home in Alligator Point
5 out of 5 average rating, 32 reviews

Tucked Away Private Beachfront Home

IreneRating, 5 stars3 months ago
Beautiful home on private beach. Our second time here. Highly recommend for a peaceful beach getaway
Superhost
A three-story beach house is observed amid natural surroundings, featuring a light exterior and a metal roof. Large windows allow abundant light to filter in, while palm trees accentuate the entrance. A spacious driveway area is visible with gravel and greenery on either side.
Home in Saint George Island
4.72 out of 5 average rating, 100 reviews

Oceanview, Private beach in gated community

AmyRating, 5 stars1 day ago
This is our 2nd time staying at Zenghai’s place and we enjoyed it as much as the first time. This visit, we were 3 couples, so each couple had a private room + bath. Importantly, the kitchen was well-equipped and the DR had a large table, which worked well for group meals. The house was spotless and the beach, a short walk away, was lovely. Hope to return again!
Guest favorite
An aerial view captures the serene landscape of Summer Camp Beach Resort, featuring a sandy shoreline bordered by lush greenery. The image showcases several cottages nestled among tall pines and oaks, indicating a peaceful retreat surrounded by nature.
Home in Saint Teresa
4.92 out of 5 average rating, 64 reviews

Cozy coastal cottage w/pool and dogs are welcome!

JenniferRating, 5 stars1 week ago
We loved our trip to Summer Camp. The house was beautiful and comfortable. Our host was very responsive and helpful. The location is amazing if you are looking for a sense of seclusion and relaxation. The screened back porch and private backyard space are wonderful. The beach is natural and seems like a private oasis. The kids enjoyed the shallow water and finding a variety of marine life. St. George Island is beautiful and close by as well as the aquarium and several cute small towns. Angelo’s Seafood is a wonderful place for delicious seafood and steaks. Wonderful vacation. Will definitely return.
Top guest favorite
A coastal house features a light-colored exterior and a metal roof, elevated on stilts above the sandy ground. A set of stairs leads up to a spacious deck, while expansive windows offer views of the surrounding nature.
Home in Alligator Point
4.96 out of 5 average rating, 50 reviews

Reel Paradise beachfront House

PatRating, 5 stars3 months ago
Saw lots of sea life - dolphins, pelicans, sea gulls, otter, herons, eagles. We saw the dolphins swarming the fish. Awesome sight. Lots of deer in the park across the road. Plenty of privacy. House very spacious - plenty of storage areas. Lots of windows for viewing the gulf activity. Great deck.
Guest favorite
Home in Alligator Point
4.95 out of 5 average rating, 65 reviews

Direct beachfront private luxury villa Sea La Vie

SebastienRating, 5 stars4 days ago
We were looking for a quiet place to enjoy widlife, sea, sun and beach with our 2 boys and we found Marcin's Sea La Vie House. That's was a perfect match. This house is very nice, well maintained, well equipped and well organized. I could spend all my time taking pictures of Dolphins and birds from the wonderful porch. We enjoyed being there and we will certainly be back.
Guest favorite
The image captures a tranquil swimming pool under a screened enclosure, reflecting the vibrant colors of a sunset. Lush potted plants are positioned near the pool, and wooden decking is visible, enhancing the serene outdoor ambiance.
Home in Eastpoint
4.89 out of 5 average rating, 28 reviews

Eastpoint on the Bay- Private Beach, Pool, Sunsets

HollyRating, 5 stars7 months ago
What a wonderful place to create lifelong memories with family and friends! The home was very spacious and was furnished with almost everything you need for your stay! Our family throughly enjoyed our time!

Quick stats about vacation rentals in Panacea

  • Total rentals

    20 properties

  • Nightly prices starting at

    $80 before taxes and fees

  • Total number of reviews

    790 reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Wifi availability

    20 properties include access to wifi

Frequently Asked Questions

  • Are there pet-friendly vacation rentals in Panacea?

    Four-legged friends are welcome in Panacea. Choose from more than 10 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in hotel rentals in Panacea?

    Experience the best of Panacea with our hotel rentals, starting at about $150 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

Destinations to explore

  1. Airbnb
  2. United States
  3. Florida
  4. Wakulla County
  5. Panacea