Vacation rentals in East Prairie

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Top-rated vacation rentals in East Prairie

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Cabin in Black River Township

4.98 out of 5 average rating, 66 reviews

Well-Designed Cozy Cabin near lake and hiking

Designed for families as a relaxing spot to get away from the hustle & bustle of life, the "Hillside Hideaway" is a 2 bedroom, 1 bath cabin perched on a hill in southeastern Missouri with a gorgeous sunset view from the screen porch. We have a well-stocked kitchen, laundry, fire pit, and plenty of toys and games for the whole family. It is just a couple of miles to a sandy swimming beach at Lake Wappapello, the boat ramp at Chaonia Landing, and many hiking trails in Lake Wappapello State Park.

Guest favorite

Cabin in Golconda

4.96 out of 5 average rating, 105 reviews

Shawnee Pines Lodging - #1 Loft Cabin

Starlink wifi now available! 2 bed/1 bath cabin with loft is located off the beaten path. Sits on 40 acres with 2 other rentals. Cabin is closest to the pond with a sand beach and a concrete pad with lounge chairs . 1 king bed, 1 queen bedroom, and a loft with a queen bed and a twin. Full bath with tile step in shower. Fully functional kitchen with all pots, pans, dishes, spices, utensils, etc. Outside you have a wrap around porch, charcoal grill and fire pit with swing away cooking grate.

Guest favorite

Cabin in Alto Pass

4.99 out of 5 average rating, 256 reviews

Ma's Cabin, Alto Pass, IL. Fine country lodging.

Cute and country remodel done in 2019. Recent new appliances, furnishings, flooring, heat & A/C, washer & dryer. Cabin is secluded and quiet plus 1/2 mile from Alto Pass Lookout Point and right in the middle of many award-winning wineries. 15 miles from Carbondale 4 miles from Giant City 30 miles from Garden of the Gods 6 lakes within 10-mile radius Hundreds of miles of hiking trails in nearby Shawnee National Forest 6 miles from Bald Knob Cross Please, no dogs! No smoking in cabin!

Guest favorite

Treehouse in Greenville

5 out of 5 average rating, 219 reviews

Secluded couple's treehouse "The Roost" w/hot tub

"The Roost" is rustic but not primitive treehouse 2 hrs south of St Louis near Wappapello Lake. Yes it has indoor plumbing & running water. Accommodates two adults, has a fully equipped kitchen and breakfast items are provided for you to cook. Surrounded by thousands of acres of national forest. Observe wildlife sightings from the deck while soaking in the hot tub, sleep comfortably in a queen size pillowtop Serta bed on a Motion Air base, and relax as you enjoy the ambience of the fireplace.

Guest favorite

Home in Goreville

4.83 out of 5 average rating, 53 reviews

New Lakefront Nature's Way Getaway Lake of Egypt

Brand new lakefront 3 bed, 2 bath home. Large master bedroom has private bath with huge tub. Other 2 bedrooms have own decks. Washer/dryer. Firepit, gas grill. Kayak, 12 foot lilypad float and paddleboat included with rental. Large stocked kitchen. Knotty pine sunroom. Beautiful views all around. The sky at night is breathtaking. Near amazing hiking and gorgeous wineries. Spend all day playing in lake & fishing, enjoy sunset on the deck or go antiquing & hiking. Have a peaceful magical vacatio

Guest favorite

Home in Cobden

4.92 out of 5 average rating, 51 reviews

Wine trail, views, hot tub, pool…

Forget your worries in this spacious and serene space. Whether you are enjoying the wine trails, a girl’s trip, hiking the trails, a family vacation or even a fishing trip, our place is the place for you! Take in all the area has to offer and then relax and rest easy in the comfort of our home. End your day relaxing by the pool, soaking in the hot tub, or enjoy a nice campfire. Very close to Bald Knob Cross. Come stay and wash your worries away! Cameras actively recording at all times.

Guest favorite

Home in Piggott

5 out of 5 average rating, 20 reviews

The Little Zebra Cottage

Your family will be close to everything when you stay at this centrally-located place. Accessible from both Main Street as well as two side streets, the side driveway can accommodate multiple cars or recreational vehicles. The address is walkable to restaurants, groceries, school facilities, and even church establishments. Local festivities, family events, and museums often draw visitors to this quaint town and our AirBnb provides the perfect place to rest at the end of a long day.

Guest favorite

Home in Gilbertsville

4.99 out of 5 average rating, 164 reviews

VIOLA'S LITTLE FARMHOUSE QUITE SECLUDED SPACIOUS!

Newly remodeled farm house - on 10 acres - beautiful setting - quite private setting - approx 2 miles from Kentucky Lake - and boat ramp at Rocky Point. Large open area for your boat and trailer - outside receptacles for charging your boat batteries. Large great room - 65" TV - sports channels - DVD player. Complete kitchen - fully stocked for preparing meals - ice maker and trash compactor. This house is extremely roomy and very comfortable. THIS IS A NON SMOKING RENTAL!

Guest favorite

Home in Alto Pass

4.99 out of 5 average rating, 115 reviews

The Farmhouse in Rhine Valley

Newly renovated Farmhouse in Alto Pass situated between Trail of Tears State Forest and just a hike or short drive away from Bald Knob Cross and wilderness. Minutes away from local wineries. Enjoy a peaceful pause from the hustle and bustle in our private little Farmhouse. Perfect for single family or small groups. Nearby venues and activities include: hiking, fishing, public hunting, wineries, restaurants, and many other local venues and events. Hunters are welcome.

Guest favorite

Home in Lost Creek Township

4.88 out of 5 average rating, 83 reviews

Camp Bluegill Lake House

New, modern, and cozy with tons of amenities and activities. Relax in the hot tub overlooking the private lake or lounge on the private beach and watch the kids have fun in the paddle boat. Beautiful, secluded property on 5 acres. Tons of parking and easy in and out access for trailers and covered parking. Minutes from beaches, boat ramps and marinas on beautiful Lake Wappapello. Multiple state parks, trails and recreational activities also within minutes.

Guest favorite

Home in Cobden

5 out of 5 average rating, 13 reviews

Domaine de Champagne

A menities, B eauty, C alm, D aydreaming, E uphoria, F un, G iant City State Park, H iking, I forgot, J ust because, K inship....POOL... SOUTHERN ILLINOIS...WINE TRAIL... YOU fill in the rest.... 2 Secluded acres just for you! Master Suite...Wow, Pool, Cooks Kitchen, Wrap Around Deck, Indoor/Outdoor Living. Everything you want. Honestly, it's just a wonderful place to be, your own oasis. No Passport needed. Pool is closed for season 10/1/24- 4/15/25

Guest favorite

Cabin in Brookport

4.96 out of 5 average rating, 114 reviews

Beautiful Lakefront Cabin with Hot Tub!

Brand new lakefront cabin!!! Escape the chaos of life in this cozy cottage on the beautiful Hohman Lake. This 1 bedroom cabin is nestled on an 80-acre private lake perfect for fishing and kayaking. A peaceful retreat off the beaten path, yet only minutes from town.