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Boutique hotel vacation rentals in Mississippi River

Find and book unique boutique hotel rentals on Airbnb

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Popular amenities for Mississippi River boutique hotel rentals

Family-friendly boutique hotels rentals

Guest favorite
A wooden door with a 'Welcome' sign opens to reveal a colorful living area. A blue couch is positioned against the wall, complemented by decorative pillows. Tropical artwork and curtains decorate the space, creating a casual beach-themed ambiance.
Hotel room in East Peoria
4.9 out of 5 average rating, 63 reviews

Beach Room! Clean Comfy room! Fun Theme! My Fav!

JaelenRating, 5 stars2 weeks ago
Pete is an amazing host me and my boyfriend will definitely be back ! It is such an amazing experience at medley manor ! All the rooms are amazing and unique in their own ways and Pete is an amazing host that does everything in his power to make your stay the best experience ! We will be back soon!
Superhost
A cabin is set amongst lush greenery, featuring a wooden deck with railing and multiple windows. The exterior displays a mix of dark brown siding and light accents, while the inviting lawn is framed by tall trees, creating a serene outdoor environment.
Hotel room in Williams Bay
4.65 out of 5 average rating, 31 reviews

Corner Cabin on Geneva Lake/Pet Friendly

BrianRating, 5 stars19 months ago
Very clean and simple units, exactly as advertised. There is a nice shared outdoor area too. Can’t beat the location, close enough to all the shops and restaurants downtown, yet far enough away where it’s quiet.
A round wooden dining table is surrounded by six matching chairs in a sunlit room. Large windows reveal a scenic view of the beach and gulf beyond, with natural light flooding the space. A ceiling fan provides a cooling breeze, enhancing comfort.
Hotel room in Grand Isle
4.89 out of 5 average rating, 28 reviews

Gulf Front Suite - 2 Bedrooms with Kitchen

DannyRating, 5 stars3 weeks ago
walking out onto the large deck that sits above the levy an having a nice chair waiting for you. It was wonderful
Guest favorite
The exterior of the Courtland Hotel showcases red brick architecture, featuring large windows with green trim. A sidewalk runs alongside, complemented by planters and benches, enhancing the inviting atmosphere of the surrounding downtown area.
Hotel room in Fort Scott
4.9 out of 5 average rating, 68 reviews

Charming Historic Hotel lodging

CaseyRating, 5 stars1 month ago
Would 10/10 recommend this to anyone looking for a unique stay. The rooms are up several stairs so if stairs aren’t your thing, then this is not for you. The hosts were amazing and very responsive to messages and wonderful to visit with.
Guest favorite
The exterior of the Shepherd's Suite is characterized by a striking black facade, accented with red wooden paneling. A warm-toned door with a grid-patterned window is visible, alongside two large, bright windows that allow natural light into the room.
Hotel room in Hermann
4.95 out of 5 average rating, 44 reviews

Hermann Crown's New Pet Friendly Shepherd's Suite

CassieRating, 5 stars5 days ago
The place was just a described. We liked the location was walkable and that we had access to the hotel amenities, but felt like we had a private space.
Superhost
An entryway is shown with a view into a room featuring exposed brick walls and large windows. Two green chairs with a small table sit beside a floral arrangement. A bed is positioned in the background, with a lamp illuminating the space. Decorative wall art adds character.
Hotel room in Milwaukee
5 out of 5 average rating, 3 reviews

Kinn Guesthouse Bay View - Suite #7

AnnaRating, 5 stars96 months ago
Kinn feels like a home away from home for me, and made me feel like a local during my job transfer. Bay View is a great neighborhood that has the best in MKE restaurants, bars, coffee shops, shops, etc. Kinn is close to it all while still being in what feels like a residential area. Would never stay downtown again or allow any of my friends and family to do so. I now live here and I will always have out of town guests who don't stay with me book at Kinn. The rooms are clean, the fridge is always stocked (wine and farm fresh eggs? yes, please!) and there is an incredible restaurant downstairs if you want to be lazy. What more could you ask for??
Guest favorite
Hotel room in New Orleans
4.98 out of 5 average rating, 43 reviews

Just blocks to Frenchman St & the French Quarter!

SamanthaRating, 5 stars2 months ago
We loved this location! It is in walking distance to Bourbon Street. It was perfect for our quick trip to see the city! It is also directly across the street from a Starbucks!! I will definitely book here again in the future.
Guest favorite
A welcoming guest room features a queen-sized bed with a brass frame and patterned bedding. A wooden side table is positioned beside the bed. A small work desk and chair are situated near the window, while soft lighting casts a warm glow in the space.
Hotel room in St. Louis
4.87 out of 5 average rating, 631 reviews

Evergreen Room Queen Bed at BnB in CWE

NettaRating, 5 stars1 month ago
Not only was the stay perfect my partner left his cellphone at the Airbnb and without hesitation they shipped his phone out for us very kind and caring people !

Boutique hotels rentals with a patio

Superhost
The room features a full-size bed with a decorative light-colored coverlet. A vintage-style lamp sits on an ornate nightstand beside the bed. Framed black-and-white photographs are arranged on the wall, complementing the textured, exposed brick backdrop.
Hotel room in Osceola
5 out of 5 average rating, 10 reviews

Historic Commercial Hotel(1868)Karolyn Grimes Room

KevinRating, 5 stars9 months ago
This is a neat little spot. Definitely felt like an old west hotel in terms of decor. Simple room and to the point. Comfy bed. I know this town since I'm from the area, but there's good printed info in the room for the local spots to check out. On the town square, so great if you're visiting for a car show! Easy parking (I was in a Uhaul).
Guest favorite
The exterior of the Vivian Fire House is depicted, featuring a vintage red fire truck parked in front. The building is painted in a soft pink hue with the 'VIVIAN FIRE HOUSE' sign prominently displayed above. Surrounding elements include a well-kept lawn and ornamental details.
Hotel room in Vivian
4.88 out of 5 average rating, 41 reviews

Historic Firehouse in charming small town America.

JenniferRating, 5 stars2 weeks ago
The Firehouse in Vivian is such a beautiful space. The accommodations are modern and beautiful, focusing on the beautiful history of the firehouse. The highlights are the fireplaces in the master bedroom and living room and the absolutely wonderful shower, offering a rain shower and side jets. We will definitely be back if we come to Vivian in the future. Thank you for a memorable experience!
Top guest favorite
A cozy studio features two queen beds with beige quilts and matching bedside tables. Soft light is provided by a lamp next to one bed. Light curtains frame the windows, and a floral wall art piece adds a decorative touch to the room.
Hotel room in Mead
5 out of 5 average rating, 13 reviews

Reel Em Inn: Spacious Studio/ 1 Mile to Lake

CoriRating, 5 stars1 month ago
I can’t say enough positive things about our stay here. The booking was incredibly last minute, but the peace and quiet as well as the level of comfort were just what we needed. We will be booking again this summer and can’t wait to return!!
Superhost
Hotel room in Hardy
4.97 out of 5 average rating, 30 reviews

Spring River Stonehouse Inn Lydia's Room

Bobbie JoRating, 5 stars2 months ago
This is my second stop at Ginni’s and I will definitely stay again if back in the area! She is so hospitable. I felt right at home and she was able to help with anything I needed. Journey (the family dog) was a bonus!!
Guest favorite
A spacious king suite features a large bed with soft linens, complemented by a cozy armchair and a stylish lamp. A separate jacuzzi tub is situated nearby, and natural light flows in through the window, illuminating the light-colored decor and wood accents.
Hotel room in New Glarus
4.93 out of 5 average rating, 73 reviews

Chalet King Suite with Jacuzzi

AprilRating, 5 stars3 weeks ago
Absolutely loved our one-night stay! The bed and pillows were sooo comfortable, I slept like a baby. Nice size mini refrigerator, microwave, Apple TV for streaming apps, safe parking lot, stand more. The only downfall would be that it seems like the city was closed after 7pm; based on the availability of food delivery and gas station snacks. Horrible planning on my end, but I was in town for a last minute work event. I would suggest to bring your own. Highly recommend and will come back!
Top guest favorite
A modern side table with a wood finish and metal legs is positioned beside a spacious light-colored sectional sofa. A vase with fresh white flowers rests on the table, contributing to the room's inviting appearance. Large windows allow natural light to fill the space.
Hotel room in Ocean Springs
4.98 out of 5 average rating, 166 reviews

Mocking Bird Inn- Magnolia Suite

MicheleRating, 5 stars2 weeks ago
We had a great stay in the Magnolia Suite at the Mockingbird Inn. Everything was exactly as pictured and described. The space was large with a very comfortable bed and sitting area - a beautiful place to hang out and relax inside or outside on the private deck. Kim and Troy are fantastic hosts and happened to be on the property while we were there - they had great suggestions for local activities and it was fun to hear about the history of the inn. We'd definitely stay again if we return to the area.
Superhost
A bedroom features a wooden bed with intricate posts and a floral-patterned coverlet. A painting of figures is displayed on the light blue wall, accompanied by decorative artwork. Natural light fills the room, highlighting the polished wooden floor.
Hotel room in Centreville
5 out of 5 average rating, 3 reviews

Room#5 Centerville Steamboat Inn

AnnetteRating, 5 stars13 months ago
I stayed 4 nights at The Steamboat Inn. I didn't arrive til later in the evening and my GPS rerouted me. Charles helped over the phone find the inn and he stayed til I arrived. All is as described and better. Charles is a font of information and very knowledgeable about the rich history of the area. The neighbors are friendly and courteous. I espenjoyed the lovely spring weather just sitting on the front porch and relaxing. I dined at 2 very good seafood restaurants and did the Plantation home tour and museum in Franklin as recommended by Charles. I can't wait to return. Charles and Wes make you feel right at home with their southern charm and hospitality.
Superhost
A spacious King bedroom features a lavish wooden bed with intricate detailing and a light-colored quilt. A blue couch is positioned near a wooden table and mirror, while a small refrigerator is located in the corner. Calming colors and natural light enhance the inviting atmosphere.
Hotel room in Cambridge
4.83 out of 5 average rating, 6 reviews

Spacious King bedroom with well-appointed bathroom

LouisRating, 5 stars22 months ago
What a lovely place, Tony. Many thanks again for all your help! We enjoyed our stay in Cambridge and plan to return.

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