Vacation rentals in Mesa County

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Top-rated vacation rentals in Mesa County

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Top guest favorite

A two-story house is surrounded by vibrant autumn foliage, featuring warm orange and yellow leaves. The structure is composed of wooden siding and large balconies, creating an inviting presence amidst nature. The peaceful setting is ideal for enjoying views of the surrounding landscape.

Home in Paonia

4.96 out of 5 average rating, 218 reviews

Laura's View Tower - King, Fall Colors, Wifi

Nestled on a hillside with unique sweeping views, the Tower is the perfect destination for romantic escapes, remote work & family or group getaways. Entire house is yours! Laundry included. The spacious two-story house boasts a versatile open floor plan and is designed for ultimate comfort. Upstairs, enjoy the sunny private deck, king-sized bed, twin sofa couch, office desk and a spacious bathroom with oversized bathtub. The well-equipped downstairs kitchen includes range & oven plus dishwasher.

Top guest favorite

A southwestern adobe-style house is framed by lush, lavender-colored plants and smooth stone borders. The structure features warm, earthy tones with distinct architectural details and a welcoming entrance. The sky above holds a mix of clouds, contributing to the serene atmosphere.

Guest suite in Hotchkiss

4.99 out of 5 average rating, 201 reviews

Top of the Mesa Lookout Tower

Centrally located in the Grand Valley, on the edge of a Redlands Mesa, sits our Southwestern adobe style house. An outside staircase takes you up to the tower guest room. There is ample parking and a culdesac. It's fisherman friendly with a turn around driveway to accommodate dories or rafts. The valley is known for its orchards, wineries and vineyards. Explore the Black Canyon of the Gunnison National Park. If you like getting away to a peaceful and quiet retreat, this is the place for you.

Top guest favorite

A covered porch is supported by wooden beams, featuring outdoor seating arranged on a textured rug. Large windows reflect the golden hour light, blending the indoor and outdoor spaces. Scenic views extend beyond the deck, highlighting the natural surroundings.

Guesthouse in Cedaredge

4.98 out of 5 average rating, 191 reviews

Yonder Mountain Retreat

A beautiful guesthouse on 5 acres a few miles north of the quaint town of Cedaredge. Multiple access points to the Grand Mesa, the ultimate outdoor playground for snowmobiling, hiking, motorcycling, ATVs, UTVs, fishing & hunting! Extra parking for motorcycles, ATVs, UTVs, or snowmobiles! YMR permits guests to bring one furbaby without pre-approval ($100 pet fee still applies). To bring more than one pet, pre-approval & addt’l. fees apply. One external security camera by the kitchen door.

Top guest favorite

A contemporary home is presented with a wooden exterior, surrounded by a gravel area. Large glass doors offer views into the interior space. Two outdoor chairs are positioned on the patio, with wildflowers and vegetation framing the scene.

Home in Loma

5 out of 5 average rating, 607 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Top guest favorite

The exterior of a rustic barn-style structure is presented, featuring warm brown siding and a prominent Colorado flag. The building includes a balcony above the entrance, flanked by double garage doors. A gravel area is visible in the foreground, with a scenic backdrop of hills.

Farm stay in Delta County

4.98 out of 5 average rating, 103 reviews

Loft Apartment on Horse Ranch

Tongue Creek Ranch offers everything from beautiful views of the famous Grand Mesa and Adobe Buttes to the peaceful sounds of creeks flowing around the property. Our petting zoo has 6 of the sweetest Nigerian Dwarf Goats, chickens, and the star of the show, BoMama our miniature donkey. Make a bonfire or visit a number of wineries, fishing holes, mountain hikes, snowboarding and skiing, boating, 4x4 trails, skydiving, scenic mountain towns, historical museums, national parks and more.

Superhost

A modern guest house with large windows showcases a stone patio area featuring various seating options. A flag flutters in the breeze, and a fire pit is centrally located, providing an inviting space for relaxation. The surrounding landscape includes distant mountains and greenery.

Guesthouse in Clifton

4.82 out of 5 average rating, 383 reviews

Colorado river guest house

Welcome to Happy Tails animal sanctuary we are a nonprofit animal rescue in palisade wine country. 10 acre animal sanctuary w alpaca, goats, pigs, dogs, chickens peacocks even a emu that all free range. Fish, kayak, paddleboard, canoe on our 2 acre fully stocked fishing lake. Float the Colorado river from Riverbend park in Palisade to our private beach. The views of the Colorado river, Grand Mesa & mount Garfield are breathtaking the animals are all friendly and love people

Guest favorite

A modern house is set against a clear night sky filled with stars. The exterior features large glass doors, providing a seamless view of the surroundings. A spacious patio area is visible, bordered by natural landscaping, creating a sense of tranquility and connection to nature.

Home in Palisade

4.97 out of 5 average rating, 135 reviews

Rapid Creek Retreat

High above the town of Palisade, nestled in the foothills of the Grand Mesa, is the Rapid Creek Retreat. Surrounded by untouched public land you will experience the true gift and grit of Colorado. Enjoy views of the big sky from sunrise to sunset and beyond for magical star gazing. We planned for this home to be ours, every detail of this home was built with intent and love. The feeling here is truly special. For those ‘rough around the edges. Sincerely, The Busch’s

Top guest favorite

A two-story house is seen from the outdoor area, featuring a patio with several chairs and tables. A gravel driveway leads to lush vineyards in the background, framed by distant mountains under a clear blue sky.

Home in Palisade

5 out of 5 average rating, 123 reviews

Love Orchard

You will enjoy breathtaking endless views of orchards, vineyards and the Bookcliff mountains and amazing sunsets from the bright, open great room and balcony. You may think you are in the clouds! The peace and quiet you will feel in this lovely new home will surely refresh you. Located on the fruit and wine byway, there are 6 wineries within 3 miles yet you are only 2.5 miles from downtown Palisade and its plentiful offerings. This home is calling your name!

Top guest favorite

The exterior of the property features a unique stone façade, complemented by a tiled roof. Surrounding landscaping includes gravel pathways and shrubbery, with towering red rock formations rising in the background under a vibrant sky. Large windows are visible, allowing for scenic views.

Apartment in Grand Junction

4.99 out of 5 average rating, 197 reviews

Luxury Apartment at Castle MVP - Sleeps 4!

THIS IS NO ORDINARY AIRBNB! Monument Vista Place is located just 3 miles from the I-70 freeway, and the quaint town of Fruita Colorado. Gated, safe and quiet, MVP offers EPIC views of Colorado National Monument! We are pet friendly because we know the challenges of traveling with our fur babies. We welcome responsible, like-minded, pet owners. Come enjoy a restful and luxurious stay, whether you're just traveling through or looking for a get-a-way!

Top guest favorite

A circular seating area made up of four wooden chairs surrounds a stone fire pit, set on a gravel base. Lush green grass and various trees provide a natural backdrop, while sandstone formations rise in the distance under a clear blue sky.

Guesthouse in Grand Junction

4.99 out of 5 average rating, 358 reviews

Chic 2 Bedroom Cottage with Monument Views

Mountain biking, hiking, motorcycling? It's all right here! Our newly built 2 bedroom private cottage sits at the base of Colorado National Monument and is thoughtfully designed to help you relax and unwind. Ride out the back door or take a short drive to the legendary trails of Grand Junction and Fruita. When the fun is done, rest your legs on your secluded patio and watch the sunset over the sand stone towers looming in the backyard.

Top guest favorite

The solargon is viewed from a distance, showcasing its octagonal shape and outdoor seating area. A covered porch with chairs and a small table is situated next to the entrance, along with a grill for outdoor cooking. Surrounding greenery adds a natural feel.

Tiny home in Hotchkiss

5 out of 5 average rating, 683 reviews

The Solargon

The Solargon is inspired by elements of Asian yurts, Navajo hogons and Native American hidatsa lodges. Combined with passive solar design principles, the solargon is an octagonal structure designed to take full advantage of the sun. The vaulted ceilings and plentiful windows make the solargon bright and inviting. This is a perfect spot for solo travelers or couples looking for a quiet, off the beaten path place to get away from it all.

Top guest favorite

The bedroom loft features a spacious bed with a neutral-colored blanket, complemented by wooden wall accents. Natural light enters through two skylights, while soft curtains frame the windows. Decorative elements include a round mirror and woven light fixtures, enhancing the inviting atmosphere.

Guesthouse in Fruita

4.96 out of 5 average rating, 785 reviews

Flat in Downtown Fruita w/ Private Garage Parking

Our private guesthouse is steps away from historic downtown Fruita. A cozy, clean, two-story loft attached to a private garage for secure parking. The unique guesthouse and garage are detached from the main house. Climb the ladder to the bedroom loft with skylights and enjoy our new air conditioning cooling system. Great shower and fresh linens. Private entrance. Peaceful garden. Easy access to I-70. pc#0045-23B