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Guesthouse vacation rentals in La Mesa

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for La Mesa guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in South Park
4.84 out of 5 average rating, 126 reviews

Adorable San Diego Guesthouse

AlauraRating, 5 stars2 weeks ago
I have never stayed in South Park before. This location was so fun! Lots of little places to walk to. No issues with parking.
Guest favorite
Guesthouse in La Jolla
4.83 out of 5 average rating, 155 reviews

Poolside Ocean View Studio

JeffRating, 5 stars5 months ago
I was looking for a peaceful and comfortable place to relax and recharge and this fit perfectly. Anita and Brian are great hosts, friendly and helpful but still respected my privacy. The setting is also beautifully landscaped and the deck was great to have for relaxing and enjoying the water view. I can highly recommend.
Guest favorite
Guesthouse in La Mesa
4.93 out of 5 average rating, 236 reviews

Fig Tree Bungalow

LaurenRating, 5 stars4 days ago
This place was great for our quick weekend trip. Definitely worth the price.
Superhost
Guesthouse in Pacific Beach
4.83 out of 5 average rating, 360 reviews

Pacific Beach Guest House With Garage and A/C

BillRating, 5 stars1 month ago
Had a great stay at this Airbnb. hist provided excellent instructions and the space was accurately described in the listing. Was a great basecamp for visiting San Diego friends and exploring the city.
Top guest favorite
Guesthouse in Allied Gardens
4.95 out of 5 average rating, 390 reviews

The BEST NEST Clean, peaceful, private, affordable

CatalinaRating, 5 stars2 weeks ago
Love Teri’s place! Feels just like home whenever we stay there. Walking distance to Better Buzz Coffee and Vons for groceries. Everything you need is there for you to make the place feel like home away from home. Teri was a great host too, can’t recommend her enough for anyone wanting to stay in San Diego.
Guest favorite
Guesthouse in San Diego
4.93 out of 5 average rating, 190 reviews

Cosy quiet Guesthouse near SDSU

EvelynRating, 5 stars1 month ago
Guest house on a quiet street, fairly close to SDSU. It was "home base" for our stay in San Diego, while visiting family. Easy access to highways. Local stores & restaurant s nearby. Cute kitchen & patio area. Well maintained.
Guest favorite
Guesthouse in North Park
4.88 out of 5 average rating, 109 reviews

Charming North Park Cottage

ElizabethRating, 5 stars1 month ago
the space was great for our needs - two adults and two kids from the same family. it's not a big space and the barrier between the sleeping spaces does not block a lot of sound so probably not best for people who are not very close with each other! pullout couch is best for kids, not the most comfortable for adults. we loved the patio for breakfast and location was perfect. thanks for a great stay!
Superhost
Guesthouse in Spring Valley
4.88 out of 5 average rating, 202 reviews

San Diego family bungalow!

EstrellaRating, 5 stars1 month ago
Everything and the hosts were amazing, can't wait to come back again ❤️

Guest house rentals with a patio

Top guest favorite
Guesthouse in Talmadge
4.99 out of 5 average rating, 201 reviews

Adorable cottage in Talmadge

KathyRating, 5 stars2 weeks ago
Another great visit! Convenient location coupled with wonderful amenities, along with Carlos’ hospitality makes this a top choice for us when visiting San Diego to see our son!
Top guest favorite
Guesthouse in La Mesa
4.99 out of 5 average rating, 104 reviews

Private 1 BR Paradise retreat

MaryanneRating, 5 stars4 days ago
This was our second stay at Jeanne and John's beautiful Airbnb. These hosts are absolutely the best! They are responsive when needed but are not obtrusive in any way. The unit is beautifully decorated, and has any amenity you could possibly need. The mattress and bedding are very comfortable, which is something that is important to older folks like us. The location is wonderful, and the guests have a beautiful back yard that is private, beautifully landscaped, and set up for those days when you are tired of sight-seeing and just want a beautiful, poolside place to relax and unwind. We highly recommend Jeanne and John's place and hope to return again one day.
Top guest favorite
Guesthouse in La Jolla
4.98 out of 5 average rating, 198 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

HaileyRating, 5 stars3 weeks ago
1000/10 ZERO complaints! The views from the patio/front of the house are beautiful. Perfect place to go for runs/walks. My friends and I loved it! We can’t wait to come back in the summer when it’s warm. Back houses are typically not my thing but we never saw or heard anyone. Sometimes you can hear when they’re home because you can hear steps but it’s not loud. The place has everything you need: towels, extra toilet paper, utensils, cups, plates, detergent. We played music on a speaker and laughed day and night, so Sorry Atoosa if my friends and I were loud at all..
Guest favorite
Guesthouse in Chula Vista
4.94 out of 5 average rating, 139 reviews

New! Beautiful Private Casita- King Bed & Office

ChrisRating, 5 stars3 weeks ago
Really enjoyed Alberto’s place, it’s nicely tucked away and provided a nice retreat from the busy area. We were able to relax and had all of the comforts of home. We really enjoyed the comfy couch and bed which allowed us to relax after a very busy few days. Off street parking was very nice as we had a busy agenda the few days we were in town and it was nice having our car in the driveway and secure off the street. Would absolutely stay again and recommend to anyone in the area.
Guest favorite
Guesthouse in Serra Mesa
4.95 out of 5 average rating, 100 reviews

Cozy, Quiet and Private Backyard Studio Escape

SharonRating, 5 stars1 week ago
This was the perfect Air Bnb for our honeymoon in San Diego. It was in a great area, and the location was 15 minutes from everything we wanted to do! Couldn't recommend more
Guest favorite
Guesthouse in North Park
4.88 out of 5 average rating, 147 reviews

Casita with private yard and separate entrance

CamiRating, 5 stars2 months ago
This was the perfect place for a one night stay. It’s so close to a lot of good restaurants and stores. Also the perfect spot to stay if you’re looking for somewhere close to the observatory theater!
Top guest favorite
Guesthouse in North Park
4.98 out of 5 average rating, 122 reviews

New (2022) North Park Abode w/ Roof Deck

SarahRating, 5 stars3 months ago
BOOK IT! Aesthetically well done, extremely comfortable, perfect location. Really enjoyed my stay here for 5 days. Unit has everything you may need during your stay. Love this neighborhood, so many great restaurants and shops. Parking was always available. Space is squeaky clean and bed is comfy. Next time I’m in SD I will stay here again.
Guest favorite
Guesthouse in La Mesa
4.95 out of 5 average rating, 107 reviews

Violet Oasis | hot tub, kitchen, no dog fee!

KaylaRating, 5 stars1 month ago
We had an amazing little staycation over the weekend at the Violet Oasis. Extremely clean, the bed was so comfy we never wanted to leave, both parking locations easy to find and Elizabeth and Paola were super responsive. Rather than feel like we were staying at an Airbnb it felt like staying over at a friend’s place. Their passion responding to their guests, making them feel at home and providing information on what to do in the area really shows in this listing. We will be back!

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in La Jolla
4.98 out of 5 average rating, 415 reviews

Beautiful Private Villa walk to beach

SamanthaRating, 5 stars2 weeks ago
It’s was amazing staying a Kim’s guesthouse. Felt very private and peaceful. The birds sounded so beautiful in the morning, we thought it was fake at first. The flowers just outside are beautiful. The beach within walking distance was a perfect place to play, lay out, watch the sunset and surfers. We even saw dolphins one night! Just a magical time. We will definitely come back!
Top guest favorite
Guesthouse in North Park
4.99 out of 5 average rating, 159 reviews

Carrie’s North Park Casita, in Heart of San Diego

MichaelRating, 5 stars1 month ago
my wife and I had a wonderful time at Carrie's place. she thought of everything and we did not want for anything. lots of thoughtful touches throughout the Casita. when we checked in we were greeted by the cutest little white dog named Rose. she is getting on in years but was very friendly. if you need a quiet, clean, private and convenient place in San Diego you cannot go wrong with this rental. thank you Carrie for a great time. much luck to you on future rentals!
Guest favorite
Guesthouse in La Jolla
4.79 out of 5 average rating, 191 reviews

San Diego Shangri-La

JimRating, 5 stars3 weeks ago
This apartment is great for 2 people to enjoy the San Diego / La Jolla area. We stayed here for a full month. The apartment is very cozy and the hosts are absolutely fantastic! They have an office set up downstairs (in the garage) and work there most weekdays and occasionally on weekends, so you're not in a totally private house (you have your own entrance and space upstairs), but they are close by for questions. As is prevalent in the area our small dog was very welcome in this apartment. If you have a small dog be wary of coyotes that roam the area.
Guest favorite
Guesthouse in Rancho Penasquitos
4.93 out of 5 average rating, 102 reviews

❤ Cozy Private Studio w/ WD 2 Minutes from Freeway

JenniferRating, 5 stars5 months ago
Wonderful stay! Home away from home! had everything I needed for an extended stay. Will be back for sure!
Superhost
Guesthouse in Pacific Beach
4.78 out of 5 average rating, 388 reviews

Law Street Retreat

TaylorRating, 5 stars2 weeks ago
Very much enjoyed staying here! Nice and clean space, and host was great! Loved being in the heart of Pacific Beach!
Superhost
Guesthouse in Ocean Beach
4.88 out of 5 average rating, 319 reviews

Indoor/Outdoor Sanctuary in Ocean Beach

ChristinaRating, 5 stars1 month ago
Great place! We will definitely stay again!
Top guest favorite
Guesthouse in Mission Hills
4.97 out of 5 average rating, 246 reviews

Beautiful Historic Home and Gardens Near Downtown!

LindaRating, 5 stars1 week ago
My husband and I and our two adult children stayed in Sam's place for 6 nights. It's a delight. We walked to Balboa Park, visited the zoo, enjoyed the farmers market, hiked in Torrey Pines state park and biked in La Jolla. Every evening and morning we enjoyed Sam's home and garden-a true place to relax. Sam is a responsive and warm host. The proximity to the airport made arrival and departure a breeze. Highly recommend!
Guest favorite
Guesthouse in La Mesa
4.96 out of 5 average rating, 196 reviews

Cozy Coop with a View

DeanRating, 5 stars2 weeks ago
Corey's place definitely fit the bill as a relaxing and quiet destination in San Diego. We would recommend recommend this very nice place to any one. Thanks Corey for an awesome stay.

Quick stats about guesthouse rentals in La Mesa

  • Total rentals

    80 properties

  • Nightly prices starting at

    $50 before taxes and fees

  • Total number of reviews

    5.2K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with a pool

    10 properties have a pool

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