Vacation rentals in Defiance

Find and book unique accommodations on Airbnb

0 of 0 items showing
1 of 3 pages
0 of 0 items showing
1 of 12 pages

Popular amenities for Defiance vacation rentals

Stay near Defiance's top sights

Montelle Winery18 locals recommend
Historic Daniel Boone Home15 locals recommend
Chandler Hill Vineyards15 locals recommend
Klondike Park14 locals recommend
Defiance Ridge Vineyards11 locals recommend
Noboleis Vineyards10 locals recommend

Other great vacation rentals in Defiance

Guest favorite
A sunlit yard features a circular pool with clear blue water, complemented by a green inflatable and surrounded by lush greenery. Comfortable seating areas with striped cushions and vibrant umbrellas provide shaded spots nearby, creating an inviting outdoor space for relaxation.
Home in St. Louis
5 out of 5 average rating, 5 reviews

home away from home

AshleyRating, 5 stars8 months ago
Took a mini vacay to St Louis with my mom & the kiddos. 3 adults & 2 children had plenty of space for sleeping. The pool & hot tub were so relaxing. It felt so homey. We were offered fresh produce from the garden. Lots of pots & pans if you like to cook while traveling. The bar was nice if you like to relax with a drink. Everyone loved the Pac-Man machine! Tons of at home amenities like streaming channels, coffee maker, potato chips, toys for the kiddos, giant Jenga set, etc. Private & safe location. Only 20-30 mins driving to the heart of St Louis. We really enjoyed our weekend and would recommend this home to anyone needing a family spot to relax.
Guest favorite
A lakeside home features a large deck with wooden railing, accessible by stairs. Natural stone firepit is surrounded by stones in the yard. Green grass and trees provide a serene backdrop. Water toys are visible nearby, emphasizing a family-friendly atmosphere.
Chalet in Innsbrook
4.96 out of 5 average rating, 77 reviews

Beautiful 5 Bedroom Lakefront Chalet with Beach

AmandaRating, 5 stars2 weeks ago
Matt’s place is stunning. The home is on a beautiful lake in Innsbrook. The views were gorgeous. The deck was beautiful. The living space is very well situated with a large Great Room. Fireplace, Extremely comfortable bedrooms. Large workable kitchen. We were seven people and had tons of space to just relax and enjoy. There were lots of games for us to play and we took advantage of that as the weather was not great. Matt was proactive and quick to respond. I appreciate the communication. I appreciated the cleanliness. I appreciated all the great recommendations.
Guest favorite
A fenced yard is featured, showcasing a blend of wooden panels in various tones. Flowering plants line the edge, with vibrant blooms among greenery. A putting green area is visible in the foreground, accompanied by a paved pathway leading to outdoor seating.
Home in St. Louis
4.89 out of 5 average rating, 207 reviews

Home away from Home St. Louis Cnty Ladue Schools

RaphaëlleRating, 5 stars2 weeks ago
Lisa was great! I needed a calm, peaceful and clean place for 2 weeks to recover from a surgery and her house was perfect. She was flexible with my arrival and departing time as I got updates from my surgeon and always worked it out with me, even last minute. There's a nice little park and neighborhood around and the house is very comfortable. Highly recommend!
Guest favorite
A spacious living area is featured with a large sectional couch and a round wooden coffee table. An electric fireplace is positioned below a wall-mounted TV displaying a beach scene. Kitchen and dining areas are visible in the background, showcasing modern appliances and a neutral color palette.
Apartment in Central West End
4.9 out of 5 average rating, 67 reviews

The Emerald House Near Wash U & Forest Park

LauraRating, 5 stars1 week ago
We loved our stay at Inayah and Bryson's place. We were in town visiting family and it felt like we were home. The place had everything we needed for our family of four and they checked in on us throughout the stay and promptly responded to our request to set up the outdoor furniture. We cannot wait to come back and stay again!
Guest favorite
A modern kitchen features crisp white cabinetry and stainless steel appliances. A large island with bar seating for four is illuminated by pendant lights. Natural light enters through a window by the dining area, enhancing the open and functional design.
Home in St. Louis
5 out of 5 average rating, 39 reviews

Bright Urban Comfort by JZ Vacation Rentals

JoshRating, 5 stars3 weeks ago
We really enjoyed our rental. The house was spacious, comfortable, and in a great location. Would definitely recommend!!
Guest favorite
A modern kitchen area features dark wooden cabinets and a granite countertop. An espresso machine is positioned beside a carousel of coffee pods. Stainless steel appliances are visible in the background, complemented by a vibrant painting of colorful umbrellas on the wall.
Home in O'Fallon
5 out of 5 average rating, 10 reviews

Quaint and Cozy Hamlet

SavannaRating, 5 stars2 weeks ago
My cousin was getting married and we needed a place to get ready. This house was PERFECT! Kevin was so incredibly nice letting us check in early and check out late to accommodate our wedding party. He went out of his way to make sure everything was exactly how we needed it. You don’t come by many people like that anymore! So blessed and thankful for Kevin and his generosity. Will definitely stay at this house again if I’m in the area!
An aerial view displays a large rectangular pool surrounded by a spacious patio area. Multiple lounge chairs are arranged around the pool, and shaded seating areas are highlighted with umbrellas. A designated grilling area is visible, adding to the outdoor amenities.
Cottage in Saint Clair
5 out of 5 average rating, 5 reviews

Guesthouse at Pinemark

BobbyRating, 5 stars6 months ago
Perfect for a wedding in town. Had plenty of room for multiple guests. Would stay here again
Top guest favorite
A cozy living area is highlighted by a stone fireplace and two windows allowing natural light to enter. A comfortable blue sofa and a wooden coffee table complement the space, while a dark armchair is positioned for relaxation. The light-colored walls and floor enhance the inviting atmosphere.
Home in Grafton
4.98 out of 5 average rating, 93 reviews

Cozy Cottage off Main Street in Grafton

LeoRating, 5 stars1 month ago
The cottage was perfect for our weekend getaway! Linda was responsive, kind, and helpful. The space was clean and cozy. Highly recommend if you want a cute space close to the fun shops and restaurants in Grafton!

Quick stats about vacation rentals in Defiance

  • Total rentals

    10 properties

  • Nightly prices starting at

    $70 before taxes and fees

  • Total number of reviews

    340 reviews

  • Wifi availability

    10 properties include access to wifi

  • Popular amenities

    Kitchen, Wifi, and Pool

  • Local attractions

    Defiance Roadhouse, Defiance Ridge Vineyards, and Good News Brewing Company Defiance

Destinations to explore

  1. Airbnb
  2. United States
  3. Missouri
  4. St. Charles County
  5. Defiance