
Vacation rentals in Defiance
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Top-rated vacation rentals in Defiance
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Popular amenities for Defiance vacation rentals
Other great vacation rentals in Defiance
Guest favorite

Home in St. Louis
5 out of 5 average rating, 5 reviewshome away from home
AshleyRating, 5 stars8 months ago
Took a mini vacay to St Louis with my mom & the kiddos. 3 adults & 2 children had plenty of space for sleeping. The pool & hot tub were so relaxing. It felt so homey. We were offered fresh produce from the garden. Lots of pots & pans if you like to cook while traveling. The bar was nice if you like to relax with a drink. Everyone loved the Pac-Man machine! Tons of at home amenities like streaming channels, coffee maker, potato chips, toys for the kiddos, giant Jenga set, etc. Private & safe location. Only 20-30 mins driving to the heart of St Louis. We really enjoyed our weekend and would recommend this home to anyone needing a family spot to relax.
Guest favorite

Chalet in Innsbrook
4.96 out of 5 average rating, 77 reviewsBeautiful 5 Bedroom Lakefront Chalet with Beach
AmandaRating, 5 stars2 weeks ago
Matt’s place is stunning. The home is on a beautiful lake in Innsbrook. The views were gorgeous. The deck was beautiful. The living space is very well situated with a large Great Room. Fireplace, Extremely comfortable bedrooms. Large workable kitchen. We were seven people and had tons of space to just relax and enjoy. There were lots of games for us to play and we took advantage of that as the weather was not great. Matt was proactive and quick to respond. I appreciate the communication. I appreciated the cleanliness. I appreciated all the great recommendations.
Guest favorite

Home in St. Louis
4.89 out of 5 average rating, 207 reviewsHome away from Home St. Louis Cnty Ladue Schools
RaphaëlleRating, 5 stars2 weeks ago
Lisa was great! I needed a calm, peaceful and clean place for 2 weeks to recover from a surgery and her house was perfect. She was flexible with my arrival and departing time as I got updates from my surgeon and always worked it out with me, even last minute. There's a nice little park and neighborhood around and the house is very comfortable. Highly recommend!
Guest favorite

Apartment in Central West End
4.9 out of 5 average rating, 67 reviewsThe Emerald House Near Wash U & Forest Park
LauraRating, 5 stars1 week ago
We loved our stay at Inayah and Bryson's place. We were in town visiting family and it felt like we were home. The place had everything we needed for our family of four and they checked in on us throughout the stay and promptly responded to our request to set up the outdoor furniture. We cannot wait to come back and stay again!
Guest favorite

Home in St. Louis
5 out of 5 average rating, 39 reviewsBright Urban Comfort by JZ Vacation Rentals
JoshRating, 5 stars3 weeks ago
We really enjoyed our rental. The house was spacious, comfortable, and in a great location. Would definitely recommend!!
Guest favorite

Home in O'Fallon
5 out of 5 average rating, 10 reviewsQuaint and Cozy Hamlet
SavannaRating, 5 stars2 weeks ago
My cousin was getting married and we needed a place to get ready. This house was PERFECT! Kevin was so incredibly nice letting us check in early and check out late to accommodate our wedding party. He went out of his way to make sure everything was exactly how we needed it. You don’t come by many people like that anymore! So blessed and thankful for Kevin and his generosity. Will definitely stay at this house again if I’m in the area!

Cottage in Saint Clair
5 out of 5 average rating, 5 reviewsGuesthouse at Pinemark
BobbyRating, 5 stars6 months ago
Perfect for a wedding in town. Had plenty of room for multiple guests. Would stay here again
Top guest favorite

Home in Grafton
4.98 out of 5 average rating, 93 reviewsCozy Cottage off Main Street in Grafton
LeoRating, 5 stars1 month ago
The cottage was perfect for our weekend getaway! Linda was responsive, kind, and helpful. The space was clean and cozy. Highly recommend if you want a cute space close to the fun shops and restaurants in Grafton!
Quick stats about vacation rentals in Defiance
Total rentals
10 properties
Nightly prices starting at
$70 before taxes and fees
Total number of reviews
340 reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
Defiance Roadhouse, Defiance Ridge Vineyards, and Good News Brewing Company Defiance
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- Busch Stadium
- Enterprise Center
- Six Flags St. Louis
- Saint Louis Zoo
- Gateway Arch National Park
- Central West End
- Missouri Botanical Garden
- City Museum
- Hidden Valley Ski Resort
- Castlewood State Park
- St. Louis Aquarium at Union Station
- Saint Louis Science Center
- Meramec State Park
- Cuivre River State Park
- Pere Marquette State Park
- Adventure Valley Zipline Tours and Paintball Park
- Raging Rivers WaterPark
- Cathedral Basilica of Saint Louis
- Grafton Winery the Vineyards
- Missouri History Museum
- St. Louis Country Club
- Boone Valley Golf Club
- The Winery at Aerie's Resort
- Bellerive Country Club
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