Vacation rentals in St. Charles County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in St. Charles County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost

A spacious living area is highlighted by a light-coloured sofa adorned with pillows and a throw blanket. A coffee table sits centrally on a patterned area rug, with natural light streaming through a large window. Decorative wall art and a plant add warmth to the space.

Apartment in Maryland Heights

4.77 out of 5 average rating, 53 reviews

Modern Retreat w King-bed | near Airport|Hospitals

This beautifully renovated two-bedroom apartment, located on the 1st floor, offers a perfect blend of comfort and convenience in the serene, picturesque community of Maryland Heights. With modern finishes that flood the space with natural light, it offers an inviting and contemporary living experience. Located just minutes from Creve Coeur Lake, the Hollywood Amphitheater, and the historic charm of St. Charles, this location offers easy access to a wide range of dining and entertainment options.

Top guest favorite

A formal dining room features a dark wooden table surrounded by six chairs. A vintage chandelier hangs above the table, complemented by large windows with dark drapes. An ornate fireplace with decorative accents adds character, while a cozy seating area includes a patterned armchair.

Apartment in St. Louis

4.93 out of 5 average rating, 231 reviews

Historic Victorian, Safe, Cozy 2nd Floor

First, check out all 4 of our private 5 Star listings that creatively combines the old with the new. If one is unavailable, check the others by going to “My Profile” and scrolling down until you see all 4. This Historic building; built in 1896 has changed missions through the years; From church, to merc. Trade, to grocery store; quite the history have graced these walls. You’ll love our safe, Southwest Gardens area; next to the famous “Hill” offers unmatched restaurant, shops, bakeries

Guest favorite

The image captures a charming street scene at sunset, with softly twilight colors illuminating the sky. Historic buildings line the street, and street lamps cast a warm glow, enhancing the inviting atmosphere of the neighborhood. Vehicles are parked along the cobbled road, suggesting a serene evening.

Home in Saint Charles

4.94 out of 5 average rating, 141 reviews

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

New Carpet! Adorable turn of the century home is located in Midtown St. Charles Historic District and sleeps 7. You won’t want to miss this St. Charles Charmer! Updated, fully stocked kitchen, dining room with Keurig coffee bar, living room w/75" SmartTV and plenty of seating throughout, SmartTV in 2 Bedrooms, 2 full bath, washer & dryer, outdoor gazebo w/table & chairs. Street & driveway parking. Close to area attractions: Historic Main Street, Ameristar Casino, & Lindenwood University.

Top guest favorite

A bright living area features a comfortable gray sofa and a round glass coffee table, complemented by a patterned area rug. A ceiling fan hangs above, and a dining table with sleek chairs is visible in the background, all bathed in natural light from the large windows.

Home in Saint Charles

5 out of 5 average rating, 42 reviews

Caper on Kings

LUXURY 4BD/2BA Cottage with , 4 Seasons Room, GAME ROOM, & outdoor fire pit. You will be close to everything when you stay at this centrally-located place! Minutes form Historic St Charles, Walking distance to French town and local coffee shops, restaurants, and shopping. The high end home has plenty of space for everyone! Cook your favorite dinners in the COMPLETELY REMODELED high end kitchen, enjoy conversations around the table in the all window four seasons room or remodeled game room.

Top guest favorite

The dining area features a dark wooden table that accommodates up to six guests. Bright light streams in through glass doors leading to the outdoor deck, complemented by sheer curtains. The kitchen, equipped with modern appliances, is visible in the background with a warm, neutral color palette.

Home in O'Fallon

5 out of 5 average rating, 44 reviews

O'Fallon Edge Oasis- 4bd/3bth Wooded Backyard

Constantly being cared for updated, and outfitted with all new furnishings, this welcoming retreat is the perfect spot for a memorable stay in O'Fallon. With spacious living areas, big bedrooms, multiple office areas and outdoor space, large groups will have plenty of space to work, kick back and relax with their loved ones both inside and out. Cleaned or replaced comforters/throws/linens each stay unlike competitors/hotels. Owner managed home, so we take pride in our home and hosting!

Superhost

Loft in Augusta

4.84 out of 5 average rating, 19 reviews

Augusta Studio at Halcyon Spa Bed & Breakfast

Ease into peace and tranquility while staying at this well-appointed vacation rental studio at the Halcyon Spa Bed & Breakfast. Perfect for 2, this Augusta property allows access to the on-site sauna & rejuvenating spa treatments. Continue your leisurely getaway in town when you shop at boutique retailers, indulge in a craft brew, or enjoy one of the local restaurants. Everything from award-winning wineries to riding the Katy Trail are a stone's throw away from this impeccable spot!

Superhost

A staircase with white banisters and wooden steps leads to the upper level. The exposed antique brick wall provides historical character to the space. A woven area rug is positioned at the base of the stairs, complementing the warm wooden flooring.

Loft in Saint Charles

4.84 out of 5 average rating, 148 reviews

Main Street Historic Loft

Historic loft centrally located along the St. Charles riverfront, on the north end of Main Street and just south of Frenchtown. Enjoy Frontier Park, shops, restaurants, and night scene - all within walking distance. The newly renovated 2 bedroom and 2 full bathroom apartment can easily accommodate groups of six. The completely updated kitchen has granite countertops, stainless steel appliances, and a dishwasher. Convenient in-house washer and dryer available for extended stays.

Top guest favorite

A modern kitchen is equipped with stainless steel appliances, including a gas stove and dishwasher. Open shelving showcases dishes, while a well-organized layout features several drawers. Natural light enters through small windows above the sink, and sleek countertops complete the space.

Home in St. Louis

5 out of 5 average rating, 40 reviews

Blair's Amazing House Sleeps 10 - 5 Beds - 2 Bath

Bring the family and welcome to Blairs House. Long Stays Welcome! - Stay for 30 days or more and SAVE! - Not available? Check our profile for over 30 listings in the area. 4 Bedrooms with 2 Full Bathrooms - One upstairs and One on the main level. Four Queen Beds and One King Bed. Cozy Living Room Dining Room seating for Eight Kitchen is fully stocked with all the essentials for casual cooking or thanksgiving dinner. Washer & dryer and Game Room located in Lower Level.

Guest favorite

The vibrant green entrance features large glass doors and inviting lantern-style lights. The brick wall adds a contrasting texture, while the house number is prominently displayed beside the entrance. Natural light filters through, creating a welcoming entryway.

Home in St. Louis

4.9 out of 5 average rating, 10 reviews

Exquisite Emerald At Tower Grove

Serene getaway nestled in a peaceful and safe neighborhood. Perfectly located, she offers you tranquility while being just minutes away from all the amenities you need—shops, restaurants, and parks. This charming historic retreat is thoughtfully designed with modern comforts and touches of elegance creating a warm and inviting atmosphere. At Exquisite Emerald, you’ll experience comfort, convenience, and a touch of luxury, making your stay truly unforgettable. Welcome home.

Top guest favorite

A secured one-car garage is seen, featuring a smooth concrete floor and walls painted a light color. A vehicle is parked inside, with surrounding lighting providing a red hue. The space is large enough for ample movement around the vehicle.

Home in Saint Charles

4.99 out of 5 average rating, 120 reviews

Little House By Main St -5 4K TV's- 1-75 Inch -1GB

Little House By Main St -5 4K TV's- 1-75 Inch -1GB Internet- No location has better access to so much. All the best amenities on both sides of Main Street St Charles! Walking distance from the Ameristar Casino, Texas Road House, Main Street (Honky Tonk, Big A's, Q, Thirstys), Starbucks, Taco Bell, Buffalo Wild Wings, McDonald's and the Bars / Restaurants on Main. An Awesome Location for all of the Festivals in St Charles! And secured parking in the 1 car garage!

Guest favorite

A fenced yard is featured, showcasing a blend of wooden panels in various tones. Flowering plants line the edge, with vibrant blooms among greenery. A putting green area is visible in the foreground, accompanied by a paved pathway leading to outdoor seating.

Home in St. Louis

4.89 out of 5 average rating, 207 reviews

Home away from Home St. Louis Cnty Ladue Schools

15 min to Norwood Hills CC. Centrally located in Safe St. Louis County, Olivette/Creve Coeur area near many attractions, businesses, Universities, etc. Harkte Nursery is 2 houses away with farm fresh produce!! Lambert Intl Airport 13 min 7.7 miles Busch Stadium and St. Louis Ballpark Village, The Arch 20 min 13.8 miles Washington University 13 min 6.4 miles St Louis University 10 min St Louis Zoo, Forest Park, Science Center, Art Museum

Superhost

A movie theater room features a large screen mounted on the wall, paired with comfortable seating. A plush, dark rug covers the floor, creating a cozy environment. The walls are painted in a deep blue hue, and recessed lighting provides a subtle illumination.

Home in St. Peters

4.81 out of 5 average rating, 26 reviews

Beautiful Family Retreat w/ Amazing Movie Theater

Experience pure luxury in this Airbnb. With an 85-inch TV, a master bath boasting a soaking tub and separate shower, a spacious backyard with a fire pit, private work office, movie theater with Dolby Atmos sound and popcorn maker, private parking, laundry facilities, and a large eat-in kitchen, this place has it all. All in close proximity of family entertainment, restaurants and boutique shops. Book now for an unforgettable and indulgent getaway.

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What guests are saying

Serene Cabin on the Mississippi River w/kayaking!

4.94 out of 5 average rating, 34 reviews5 months ago

My husband and I have stayed in at least a dozen AirBNBs and this is one of our favorite ones. We will *definitely* be coming again! It felt like we were in a treehouse! I LOVE natural light so having all the windows to look out at all the beautiful fall colors was amazing. The handiwork and craftsmanship of the home is impeccable. So private and serene and still just 30 minutes away from the bustling city. I greatly appreciated how VERY clean it was! No complaints at all! :) thanks Debi and Matt!

Cabin in Portage Des Sioux

What guests are saying

Florissant's Old Town Inn (3BR)

5 out of 5 average rating, 3 reviews8 months ago

What a treasure we stumbled across! If you enjoy the vibes of an older home this one is for you! The neighborhood is very safe and amazing! The actual home has glass door knobs (if you know you know). The antique ceiling lights are amazing. They do have electronic locks, which are easy to access. The baths are updated, as well as the kitchen. Everything you could need was provided. We rented the entire place, (upstairs and down). My husband and I enjoying a weekend to watch some Cardinals baseball with our two adult children and a granddog. Sitting on the back patio watching the Koi fish could not have been more relaxing. Thanks for a great adventure. I hope to be able to visit this home in the future.

Home in Florissant

What guests are saying

Stay, Work & Play, 2bd w/office near Downtown

5 out of 5 average rating, 4 reviews1 month ago

This was a clean, quiet and modern apartment. We loved the themed decor, the 1904 World’s Fair. Very charming, and we had everything we needed. Clean, well appointed. Lots of accoutrements. Seemed recently rehabbed/remodeled. Parking space included, though we used the ample street parking. Centrally located. Near Botanic Gardens and Tower Grove Park. Easy to get to downtown or other neighborhoods. We would definitely stay again if the opportunity arises. 🏆

Apartment in St. Louis

What guests are saying

Historic Haven by JZ Vacation Rentals

4.81 out of 5 average rating, 43 reviews3 weeks ago

Situated in a beautiful neighborhood and offers excellent walkability to numerous wonderful attractions, stores, and restaurants. The space itself is very spacious and features a nice kitchen and bathrooms. Whether you're looking for a comfortable base to explore the area or a relaxing place to unwind between activities, this is a great choice.

Townhouse in St. Louis

What guests are saying

Chase's Cabin in The Sky

4.83 out of 5 average rating, 41 reviews3 weeks ago

I stayed at Chase's cabin in the sky for three nights. It was exactly what I was looking for! It felt just like home. The snack bar and all the small amenities really made the difference. I also got to see a red fox running along the river and two eagles flying around! I had my two dogs with me and it was the perfect hang out to chill and regenerate.

Cabin in Saint Charles

What guests are saying

Be in the heart of Mardi Gras - Across from Duke's

4.93 out of 5 average rating, 91 reviews2 weeks ago

This place was adorable! Stayed with 3 girlfriends for a concert downtown. We came back to the Airbnb and then walked to Mollys which was a lot of fun. Safe area, beautiful buildings, coffee nearby was excellent as well! Would totally stay again.

Apartment in St. Louis

What guests are saying

Charming Cottage in Heart of New Town St. Charles

5 out of 5 average rating, 42 reviews5 months ago

I loved my stay at The Cottage! It was very clean, tastefully decorated, and smelled so nice as soon as I walked in the door. It was perfect for my stay in St Charles while attending a conference in the area. The area is beautiful and there is a great coffee shop nearby. Other restaurants and park areas are within walking distance as well. I highly recommend Lindsay's place and would love to stay there again!

Loft in Saint Charles

What guests are saying

Epic Pickleball Guest Retreat

4.97 out of 5 average rating, 32 reviews5 months ago

My husband and I spent a wonderful few nights at Renee’s pickleball getaway and it was a wonderful space for the two of us. The adjacent pb court was the real gem for us but we also enjoyed walking to local dining and shopping while we stayed. We are excited to stay here again!

Guesthouse in St. Louis

What guests are saying

Quaint and Cozy Hamlet

5 out of 5 average rating, 10 reviews2 weeks ago

My cousin was getting married and we needed a place to get ready. This house was PERFECT! Kevin was so incredibly nice letting us check in early and check out late to accommodate our wedding party. He went out of his way to make sure everything was exactly how we needed it. You don’t come by many people like that anymore! So blessed and thankful for Kevin and his generosity. Will definitely stay at this house again if I’m in the area!

Home in O'Fallon

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