
Hotel vacation rentals in Santa Cruz Department
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Santa Cruz Department
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santa Cruz Department hotel rentals
Family-friendly hotel rentals
Superhost

Hotel room in Santa Cruz de la Sierra
4.73 out of 5 average rating, 15 reviewsFully Equipped Studio - 2 people
FreddyRating, 5 stars62 months ago
Excellent service, always very friendly and ready to help. The place is very central, everything has everything first hand. 100% recommended.
Superhost

Hotel room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviewsEquipped apartment in equipetrol for 4 executives
AmancayaRating, 5 stars55 months ago
Jorge is the best host I met in Bolivia from afar Incredible attention, request airport pick up service and everything excellent! With biosafety measures and impeccable cleanliness. The 5 star price-servation ratio! Jorge is always attentive and willing to help, excellent! Options for improvement: Breakfast before 8:00 AM The best of the apartment: Location Note Cleaning Ease Host communication Would I be back? Yes, without hesitation!
Superhost

Hotel room in Santa Cruz de la Sierra
4.33 out of 5 average rating, 3 reviewsDepartment - family full equipped Equipetrol
Jaime EduardoRating, 5 stars88 months ago
A place in the best area of Santa Cruz, with everything you need for a good day in this city. Close to great restaurants and shopping malls! Jorge and his team were always on the lookout for anything.
Superhost

Hotel room in Santa Cruz de la Sierra
4.8 out of 5 average rating, 5 reviewsFurnished apartment for executives in Equipetrol
LissetteRating, 5 stars76 months ago
Jorge properties are amazing. We own three Airbnb in Miami area and we know exactly what to expect of a property. Jorge's properties achieved all our expectations and more. The personnel is super friendly and always available. If you are in Santa Cruz for vacation or business this is the place to stay. Everything is very close. Thanks Jorge! you are a 5 Star!

Private room in Samaipata
4.7 out of 5 average rating, 133 reviewsRoom "Inti" in an animal refuge centre
HannesRating, 5 stars2 weeks ago
Cheap accommodation in Samaipata. Located in the middle of a small zoo. The grounds are really cute designed, we found it very nice here. It's a bit outside, but it wasn't a problem for us. We were allowed to leave the luggage after check-out and even shower again after our hike. Thanks! ☺️ We would come back
Superhost

Hotel room in Santa Cruz de la Sierra
4.75 out of 5 average rating, 4 reviewsFurnished apartment for executives - Equipetrol
AndreaRating, 5 stars69 months ago
Jorge was an exceptional host, he helped us with a lot of inconveniences that we had we arrived. We love to be there <3
Superhost

Hotel room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviewsComfortable, spacious and equipped apartment -Equipetrol
EstherRating, 5 stars105 months ago
Hi Jorge!! The apartment is clean and in a safe place, all you need is to fix the windows to avoid the sound they make by the wind....thank you!!
Hotel rentals with a pool

Hotel room in Santa Cruz de la Sierra
3.67 out of 5 average rating, 3 reviewsNovotel SCZ - Standard Room
Juan PabloRating, 5 stars3 months ago
Nice offer, great place, a bit slow to answer tho

Hotel room in Santa Cruz de la Sierra
4.17 out of 5 average rating, 12 reviewsFeel like home !! Breakfast included !!
EricRating, 5 stars19 months ago
Excellent location to know the center of Santa Cruz, everything in order and the hosts are very friendly and helpful. I highly recommend them.
Guest favorite

Hotel room in Colinas del Urubó
4.87 out of 5 average rating, 15 reviewsComfortable Suite at Hotel Radisson
ElviraRating, 5 stars4 months ago
Excellent check-in, room and place. We'll be back for sure!
Guest favorite

Hotel room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviewsCostanera Suites
MichelleRating, 5 stars1 month ago
Excellent, the hotel staff 10/10. My boyfriend's best day because he took a picture with Duki. Fernando is an excellent host, he responds quickly.

Hotel room in Santa Cruz de la Sierra
4.67 out of 5 average rating, 3 reviews5-star suite.
MoisesRating, 5 stars13 months ago
Wonderful place…!!!
Hotel rentals with a patio
Top guest favorite

Private room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviewsPrivate room
Joel AndresRating, 5 stars1 month ago
Exelente location, very friendly and quick response, recommended.

Private room in Santa Cruz de la Sierra
4.33 out of 5 average rating, 15 reviewsDouble bed room with balcony
FernandoRating, 5 stars9 months ago
It has to improve everything the construction is old was not worth it

Private room in Santa Cruz de la Sierra
5 out of 5 average rating, 4 reviewsBeautiful suite 10 minutes from the airport
HarisRating, 5 stars33 months ago
Gustavo’s place is beyond amazing. The suite I stayed at was super spacious and had a very comfortable bed/pillow. Gustavo himself was an *excellent* host for accommodating me at 10:30pm with open arms after my overnight flight got postponed. In addition, the place is only a 15 minute drive to the airport which made going back the next morning super easy :)
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