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Apartment vacation rentals in Rochester

Find and book unique apartments on Airbnb

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Popular amenities for Rochester apartment rentals

Weekly apartment rentals

Guest favorite
Two comfortable armchairs are positioned next to a side table and a lamp, casting a soft glow. A small desk is seen nearby. Natural light filters in through a window, highlighting the light blue walls and a decorative area rug on the polished wooden floor.
Apartment in Rochester
4.97 out of 5 average rating, 38 reviews

Curated Classic a block from St. Mary's Hospital

MelissaRating, 5 stars3 months ago
Awesome place! We stayed for almost two weeks while a family member was at Saint Mary’s. It was so close, and saved us the stress and money of parking daily at the hospital. Britt was very responsive when I had a question, and provided clear instructions for checkin/out. Great experience, and would definitely stay again!
Top guest favorite
A spacious living area features elegant wood floors and warm lighting. A large window allows natural light, highlighting a red sofa and coffee table. An archway leads to an outdoor space, while a comfortable chair provides additional seating.
Apartment in Rochester
4.99 out of 5 average rating, 72 reviews

Kaleidoscope Suite 2 bd 1 mi to Mayo Free Parking

LisaRating, 5 stars2 weeks ago
We stayed at this conveniently located place for 6 weeks to help our family member recover from major surgery at the Mayo Clinic. We felt right at home and very supported by the thoughtful way Jeff and Stephanie have furnished the place, including height-adjustable beds, a shower stool and grab bars, and two comfortable electric recliners in the living room in front of a large TV. The bonus space in the partially finished basement provided extra space for privacy when needed. The hosts were incredibly responsive and generous in providing assistance when we needed it, sometimes even before we realized we needed it (such as a heads up about a coming snowstorm). As other reviews have noted, there is a small flat upstairs that is separately rented as an Airbnb (which we also have stayed in in the past, very cute) and so there was some sound of footsteps from time to time. It was easy to adjust to the sound though and everyone was respectful. Highly recommended!
Superhost
A well-arranged living area features a comfortable gray sofa alongside a small black coffee table. A dining set with two chairs is positioned near a compact kitchen equipped with modern appliances, including a microwave and stove. Natural light filters through a window with blinds.
Apartment in Rochester
5 out of 5 average rating, 4 reviews

Serene Studio| Right Across From St Marys!+Parking

MartinRating, 5 stars1 month ago
I enjoyed my stay in Rochester ! Great cozy place for few days or weeks. Has everything you need. Location is just perfect in front of Saint Marys Building. I would definitely come back here
Superhost
The living room features a comfortable seating arrangement with a full-size futon and an electric recliner. A gas fireplace is placed against a green-tiled wall, while a window allows natural light to brighten the space. A patterned area rug accents the hardwood floor.
Apartment in Rochester
4.71 out of 5 average rating, 7 reviews

Viola Suite #4 | Quiet 1BR, Lg Yard, Pets Welcome!

CassandraRating, 5 stars2 weeks ago
Highly recommend this space and host. Clean and well organized upon arrival. Clear and detailed instructions for everything, along with local recommendations. The backyard is beautiful and we saw so much wildlife during our stay. Birds, otters, woodchucks, deer and more. Walking distance to quarry hill park which is lovely. There is a bus stop about a block down the road so it was easy to get around even when we didn't have our car for a couple days. The host was incredibly quick to respond and very kind.
Guest favorite
A cozy living area is featured, furnished with a dark blue sofa adorned with decorative pillows and a white throw blanket. An orange accent chair complements the space, while a soft area rug lays beneath. Natural light enters through a small window, enhancing the inviting atmosphere.
Apartment in Rochester
5 out of 5 average rating, 36 reviews

Oasis Luxe Suite—Steps from Mayo Clinic Hospital

TerryRating, 5 stars1 month ago
If you are in Rochester for Mayo or anything else, this is THE place to stay. It was pristine, well-equipped and the host was extremely helpful and responsive. This is a close walk to Mayo facilities and was a welcomed respite to come home to. Well done on every level.
Superhost
A cozy living area is showcased with a brown sofa and two black chairs. A wooden coffee table sits in the center, accompanied by decorative plants. Natural light enters through a window, enhancing the soft color palette of the space.
Apartment in Rochester
4.67 out of 5 average rating, 3 reviews

Dreamy Den | Right Across From St Marys!+Parking

BillieRating, 5 stars2 months ago
Under a mile Walk to Mayo building. Good location. Nice Airbnb. Comfy bed. Be aware there a stairs you have to climb to get in and out.
Guest favorite
A comfortable living area is shown, featuring a dark blue sofa complemented by floral curtains. The entryway includes a decorative wall with hooks for coats and a welcome sign, while a bright yellow door adds a touch of color.
Apartment in Rochester
5 out of 5 average rating, 14 reviews

Clean, cozy, close to Mayo & Fairgrounds.

KelleyRating, 5 stars8 months ago
I stayed at Emily’s while receiving care and recovering from surgery at the Mayo Clinic. It was a great location to the gonda building and both st marys and Methodist hospital. The bedrooms were comfortable and had tvs which was such a nice aspect. Everything was clean, comfortable and as advertised. Emily was a gracious host and incredibly responsive. Close to other parts of Rochester as well outside of Mayo! But really wonderful place for my purposes.
Superhost
A spacious living area is highlighted by a medium-firm queen bed and a Flexsteel loveseat. A small dining table is positioned alongside a television. Walls are adorned with framed images, while a door leads to a private entrance.
Apartment in Rochester
4.93 out of 5 average rating, 28 reviews

Cozy, Private Studio. Near Mayo/Downtown/Parks

AndrewRating, 5 stars14 months ago
Emily was an amazing host! Checked in periodically to make sure I had everything I needed.

Private apartment rentals

Guest favorite
A bright kitchen area features modern appliances including a black stove and a white refrigerator. A dark wooden dining table is positioned centrally, surrounded by chairs. Natural light enters through sliding glass doors that open to a small outdoor space, enhancing the room's airy feel.
Apartment in Rochester
4.92 out of 5 average rating, 91 reviews

Beautiful Duplex home 5 minute walk to Mayo Clinic

KristinaRating, 5 stars14 months ago
Very welcoming. Close to Mayo. Nice for a stay at Mayo Clinic.
A spacious living area features a large, light-colored sectional sofa with soft cushions. The room is accented by modern light fixtures and decor elements, including tall decorative branches in vases. A view of the kitchen area is visible beyond, highlighting the open layout.
Apartment in Rochester
4.8 out of 5 average rating, 192 reviews

EXCEPTIONAL, CONTEMPORARY 2BD/1 BA/ CLOSE TO MAYO

MikeRating, 5 stars2 weeks ago
Everything was really nice. Perfect location close to the National Volleyball Center. Only gripe was the bathroom was not fully renovated, floor tile was incomplete and shower tile was just painted over.
Superhost
The living area is furnished with a brown sofa and a black chair, complemented by a small round table. A kitchen can be seen in the background, equipped with modern appliances. A light-colored rug lies on the floor, enhancing the space's comfort.
Apartment in Rochester
5 out of 5 average rating, 3 reviews

Cozy Nook | Right Across From St Marys!+Parking

SusanRating, 5 stars6 months ago
While here at Mayo it was a perfect location for me as it was close to the clinic. The apartment was quiet and peaceful. If I had to give a downfall it would only be that the parking, getting to the actual apartment could use a walkway of sorts as it's gravel (rocks). Would stay again. Host was great. Highly recommend.
The living area features a comfortable gray sofa adorned with decorative pillows and a stylish throw. A wooden coffee table sits on a patterned area rug, accented by a modern lamp. The backdrop includes a kitchen area with wooden cabinetry, visible in soft light.
Apartment in Rochester
4.68 out of 5 average rating, 47 reviews

♢ Mayo in 2 Blocks ♢NO STEPS/Elevator❥Private Code

SusanRating, 5 stars1 month ago
The location is very convenient if you’re visiting Rochester for appointments at Mayo Clinic. It was a short walk to my appointments at the Gonda Building and there are many restaurants within walking distance too. Jackie was extremely helpful and responsive.
A cozy living area features a light sofa draped with a throw, complemented by a glass coffee table. Natural light floods the space through sliding glass doors, which open to a patio area. A television sits on a wooden console, and a small tree adds greenery.
Apartment in Rochester
4.75 out of 5 average rating, 4 reviews

Luxury 1 bedroom Serenity

AdelRating, 5 stars6 months ago
Brand new place with a piece of mind location. Very quiet, green areas, and sidewalks around the property. Great clubhouse, gym, and amenities. Host was very friendly, responsive, and accommodating. On-site team was just as good. Highly recommend it for those who want stay in calming place while getting things done in town or Mayo Clinic.
A bright dining area is highlighted by large, arched windows with soft fabric curtains. A small white table is accompanied by two yellow chairs, offering a cheerful spot for meals, with views of the surrounding neighborhood visible through the window.
Apartment in Rochester
4.67 out of 5 average rating, 108 reviews

A Pet friendly, bright and warm, Private apartment

LeahRating, 5 stars1 week ago
Very close to the Mayo campus and hospital. Elizabeth was proactive with her communication, very friendly and gave very clear instructions on parking and how to get into the house.
Guest favorite
A living area features comfortable seating with a recliner and a neutral-toned couch. Light streams through sheer curtains, illuminating a decorative coffee table on an area rug. A desk with a lamp is positioned against the wall, providing a functional workspace.
Apartment in Rochester
4.81 out of 5 average rating, 21 reviews

5-Star 5 Mins to Mayo 2 Bedroom Discounted Duplex!

RickRating, 5 stars3 weeks ago
We stayed here because one of us had surgery at Mayo, so we didn't do things around town or use the walking trail, etc. Things we really liked in the rental: memory foam toppers on the beds made them super comfortable; plentiful outlets and USB ports that were easily accessible; well-stocked kitchen; comfortable double recliners; and a lift recliner that was a godsend after surgery. John was very responsive with a couple of issues, and was easy to communicate with. I'd highly recommend this rental.
Guest favorite
A welcoming living area features a blue sofa adorned with colorful pillows in various patterns. An abstract artwork hangs above, complementing the space. Soft, natural light enters through the large windows, which are dressed with sheer curtains, enhancing the cozy ambiance.
Apartment in Rochester
5 out of 5 average rating, 12 reviews

Penthouse Suite—Steps from Mayo Clinic Hospital

KimberlyRating, 5 stars1 month ago
We stayed in the Penthouse apartment, and it was perfect for our week of appointments at Mayo Clinic. We walked to/from appointments at the Mayo/Gonda buildings as well as to local restaurants and parks.

Apartment rentals with air conditioning

A spacious living area features a comfortable couch and armchair, paired with a wooden coffee table. A television displays an image on one wall, while soft lighting from a table lamp creates a cozy ambiance. A doorway leads to the outside, and decorative artwork adorns the walls.
Apartment in Rochester
4.33 out of 5 average rating, 18 reviews

Lovely modern 2 bedroom apartment

MohamedRating, 5 stars5 months ago
Elizabeth was friendly and welcoming. We only stayed one night and everything was good. I just had a little issue with the door and had to lock it from the inside because the key was giving me a hard time but it was manageable. the location is close to many areas which is great.
Top guest favorite
A cozy living area is presented, featuring a gray sectional sofa adorned with yellow and blue pillows. A plush throw blanket drapes over the arm. A television sits above a wooden entertainment unit, next to a fireplace, while vertical blinds allow natural light to filter in.
Private room in Rochester
5 out of 5 average rating, 12 reviews

Only minutes to Mayo Clinic

KarenRating, 5 stars11 months ago
The accommodations where clean, comfortable and safe. The host was kind, helpful, and very communicative.
Top guest favorite
A spacious studio apartment features a large bed with soft bedding, complemented by two nightstands with lamps. Natural light enters through a window with blinds. A small white coffee table lies on a dark-striped rug, enhancing the neutral tones of the room.
Private room in Rochester
4.95 out of 5 average rating, 405 reviews

Magical Nest

KevinRating, 5 stars2 weeks ago
Our stay was very relaxing and stress free. Communication was prompt and helpful.
A spacious living area is showcased, featuring a dark leather sofa with decorative pillows. A wooden coffee table sits in the center, accompanied by a flat-screen TV on a low stand. Natural light filters in through two windows, dressed with dark curtains.
Apartment in Rochester
4.67 out of 5 average rating, 12 reviews

Cozy, Private, near Mayo and Pet-friendly

PeterRating, 5 stars8 months ago
Nice, roomy upstairs suite. Very comfy bed and hot shower had plenty of water pressure (big plus for me). Full private kitchen with microwave, fridge with freezer and coffee maker/instant coffee options. There was a glitch with housekeeping getting the room ready in time, but Sandy was instantly responsive and made things right. A+++ host.
The kitchen features wooden cabinetry and granite countertops, providing ample workspace. A white gas stove and refrigerator are included. A microwave is mounted above the counter. The adjacent area reveals a glimpse of the dining space, enhancing the kitchen's functionality.
Apartment in Rochester
4.46 out of 5 average rating, 26 reviews

Mayo Discount Offered- Upper Level Duplex

GinnyRating, 5 stars11 months ago
Thank you, Mark for being so responsive and taking care of everything immediately. This would be a good place to stay for a summer internship at Mayo!
A bright living area is visible, featuring a comfortable seating arrangement with a gray couch and a reclining chair. A small wooden table sits in front. Built-in shelves display decorative items. A door in the background leads to a bedroom area, with a glimpse of a spacious bed.
Apartment in Rochester
4.24 out of 5 average rating, 71 reviews

212 Apartment

AlexRating, 5 stars4 months ago
Older community home with radiant heat. This place has the best water pressure and hot water shower I've used in decades. The home is perfectly located in an older part of rochester with diners and some cheap bars. it is also located within walking distance to high end amenities as well. Easy parking in the alley, seemed safe with some lighting. The other tenants were very quiet and respectful.
The bedroom features a dark wooden bed with layered bedding and a decorative cushion. A matching armchair sits in the corner, and a lamp is placed on a bedside table. The window is covered with a golden curtain, allowing for natural light.
Apartment in Rochester
4.7 out of 5 average rating, 10 reviews

Cozy 1 Bed 1 Bath apartment - walk to Mayo

SherenaiRating, 5 stars7 months ago
Had a wonderful stay! Clean, cozy and private. I was in town for 3 weeks while transitioning to a new job and the fact that I had a nice place to return to each day was such a relief. Great host, very responsive and he gave clear instructions on how to get in and out.
Guest favorite
Apartment in Rochester
4.83 out of 5 average rating, 12 reviews

Home Sweet Home

AmyRating, 5 stars1 week ago
Great place. Clean and comfy! Had some special cookies for us when we got there and then some cookies for our pup when we left. Very sweet host!

Quick stats about apartment rentals in Rochester

  • Total rentals

    170 properties

  • Nightly prices starting at

    $20 before taxes and fees

  • Total number of reviews

    7.2K reviews

  • Family-friendly rentals

    60 properties are a good fit for families

  • Pet-friendly rentals

    60 properties allow pets

  • Rentals with dedicated workspaces

    110 properties have a dedicated workspace

Destinations to explore