Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in North Charleston
5.0 out of 5 average rating, 112 reviewsThe Park Circle Clerestory Studio Guest House
Jul 26 – Aug 2
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 220 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Sep 22 – 29
Guesthouse in Townville
4.88 out of 5 average rating, 230 reviewsLisa’s Lodge
Jun 19 – 26
Guesthouse in Camden
4.94 out of 5 average rating, 179 reviewsRed Roof Loft @ FireFly Farm
Aug 29 – Sep 5
Guesthouse in Ridgeville
4.82 out of 5 average rating, 213 reviewsPond House Bungalow at Natural Gathering Grounds
Dec 26 – Jan 2
Guesthouse in Summerville
4.98 out of 5 average rating, 645 reviews★Delightful guest house near historic plantations★
Aug 10 – 17
Guesthouse in Beaufort
4.98 out of 5 average rating, 360 reviewsThe Wren Guest House
Jul 29 – Aug 5
Guesthouse in Salem
4.88 out of 5 average rating, 290 reviewsMountain Edge Loft
Nov 24 – Dec 1
Guest house rentals with a patio
Guesthouse in Abbeville
4.95 out of 5 average rating, 108 reviews1-bedroom guesthouse in Abbeville, SC
Nov 7 – 14
Guesthouse in Charleston
4.93 out of 5 average rating, 172 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Sep 7 – 14
Guesthouse in Johns Island
4.91 out of 5 average rating, 108 reviewsCozy Cottage! 5 mins from Kiawah!
Sep 17 – 24
Guesthouse in Columbia
4.95 out of 5 average rating, 148 reviewsRenovated One Bedroom Guest House by UofSC
May 22 – 29
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Jan 1 – 8
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Apr 14 – 21
Guesthouse in Spartanburg
5.0 out of 5 average rating, 39 reviewsThe Lodge at Pythian Park
Aug 16 – 23
Guesthouse in Campobello
4.96 out of 5 average rating, 72 reviewsBungalow on a 3 acre mini farm
Nov 27 – Dec 4
Guest house rentals with a washer and dryer
Guesthouse in Florence
4.92 out of 5 average rating, 129 reviewsMidtown Retreat - Guest House in heart of Florence
Jun 8 – 15
Guesthouse in Florence
4.99 out of 5 average rating, 668 reviewsBoho Private Downtown Stay Near I-95 & Hospital
May 21 – 28
Guesthouse in Saint Helena Island
4.99 out of 5 average rating, 189 reviewsCharming Waterfront Cottage with Beautiful Views.
Jul 24 – 31
Guesthouse in Summerville
4.97 out of 5 average rating, 218 reviewsTiny Oak Cottage in Historic Downtown Summerville
Feb 25 – Mar 4
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 409 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Dec 11 – 18
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Apr 6 – 13
Guesthouse in Lyman
4.99 out of 5 average rating, 124 reviewsBlue Heron Hideaway Lakeside Retreat
Jul 14 – 21
Guesthouse in Columbia
4.98 out of 5 average rating, 130 reviews❃ The Rosewood Loft ❃ Desk, Kitchen & Laundry
Oct 23 – 30
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