Guesthouse vacation rentals in Charleston
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Charleston
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Charleston guesthouse rentals
Family-friendly guest house rentals
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Guesthouse in North Charleston
5.0 out of 5 average rating, 111 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
Guesthouse in Charleston
4.91 out of 5 average rating, 648 reviewsIsland Oasis—Near Downtown
Guesthouse in Ridgeville
4.82 out of 5 average rating, 213 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Summerville
4.94 out of 5 average rating, 212 reviewsNina's Cottage -Historic Downtown Summerville
Guesthouse in North Charleston
4.86 out of 5 average rating, 441 reviewsPark Circle Jungalow Loft
Guesthouse in Johns Island
4.98 out of 5 average rating, 239 reviewsPrivate waterfront apt in the oaks
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Hanahan
4.99 out of 5 average rating, 76 reviewsThe Violet Villa w/ no cleaning fee
Guesthouse in Charleston
4.94 out of 5 average rating, 78 reviewsSpacious 1 bedroom cottage in Avondale
Guesthouse in Mount Pleasant
5.0 out of 5 average rating, 26 reviewsCoastal Charm: Village Hideaway
Guesthouse in Charleston
5.0 out of 5 average rating, 13 reviewsGas Light Carriage House James Island
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.99 out of 5 average rating, 142 reviewsLarge Guesthouse with Private Dock & Marsh Views
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 252 reviewsShem Creek Bungalow: Coastal Comfort Redefined
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 248 reviewsUpscale Couple's Escape | Beach & Downtown CHS
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 258 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 116 reviewsBeach, downtown, Alhambra Hall weddings so close!
Guesthouse in Charleston
5.0 out of 5 average rating, 143 reviewsThe Guesthouse at Old Orchard
Quick stats about guesthouse rentals in Charleston
Total rentals
230 properties
Rentals with dedicated workspaces
100 properties have a dedicated workspace
Rentals with a pool
10 properties have a pool
Pet-friendly rentals
50 properties allow pets
Family-friendly rentals
40 properties are a good fit for families
Total number of reviews
23K reviews
Destinations to explore
- Savannah Vacation rentals
- Hilton Head Island Vacation rentals
- Kiawah Island Vacation rentals
- Tybee Island Vacation rentals
- Folly Beach Vacation rentals
- Surfside Beach Vacation rentals
- Mount Pleasant Vacation rentals
- Hilton Head Vacation rentals
- Beaufort Vacation rentals
- Isle of Palms Vacation rentals
- Atlanta Vacation rentals
- Myrtle Beach Vacation rentals
- Guesthouse rentals United States
- House rentals United States
- Beachfront rentals Charleston
- Pet-friendly rentals Charleston
- Rentals with a washer and dryer Charleston
- Rentals with pools Charleston
- Kid-friendly rentals Charleston
- Luxury rentals Charleston
- Smoking-friendly rentals Charleston
- Family-friendly rentals Charleston
- Rentals with a fire pit Charleston
- House rentals Charleston
- Beach house rentals Charleston
- Rentals with a fireplace Charleston
- Monthly Rentals Charleston
- Waterfront rentals Charleston
- Rentals with an EV charger Charleston
- Rentals with a hot tub Charleston
- Condo rentals Charleston
- Rentals with lake access Charleston
- Bungalow rentals Charleston
- Private suite rentals Charleston
- Rentals with breakfast Charleston
- Beach condo rentals Charleston
- Hotel rentals Charleston
- Townhouse rentals Charleston
- Rentals with a kayak Charleston
- Apartment rentals Charleston
- Mansion rentals Charleston
- Cottage rentals Charleston
- Rentals with beach access Charleston
- Rentals with outdoor seating Charleston
- Rentals with an accessible height toilet Charleston
- Fitness-friendly rentals Charleston
- Villa rentals Charleston
- Bed and breakfasts Charleston
- Rentals with a patio Charleston
- House rentals Myrtle Beach
- House rentals Savannah
- Guesthouse rentals Savannah
- House rentals Hilton Head Island
- House rentals South Carolina
- Guesthouse rentals South Carolina
- House rentals Charleston County
- Guesthouse rentals Charleston County
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes