Guesthouse vacation rentals in Charleston County
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Top-rated guesthouse rentals in Charleston County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for Charleston County guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Summerville
4.94 out of 5 average rating, 213 reviewsNina's Cottage -Historic Downtown Summerville
Guesthouse in Charleston
4.91 out of 5 average rating, 650 reviewsIsland Oasis—Near Downtown
Guesthouse in Ridgeville
4.82 out of 5 average rating, 215 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 225 reviewsGreen Garden Studio @greengardenstudio2017
Guesthouse in Johns Island
4.98 out of 5 average rating, 240 reviewsPrivate waterfront apt in the oaks
Guesthouse in North Charleston
5.0 out of 5 average rating, 112 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in North Charleston
4.86 out of 5 average rating, 443 reviewsPark Circle Jungalow Loft
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 100 reviews5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!
Guest house rentals with a patio
Guesthouse in Charleston
4.97 out of 5 average rating, 131 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Charleston
4.98 out of 5 average rating, 125 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Johns Island
4.91 out of 5 average rating, 110 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Charleston
5.0 out of 5 average rating, 14 reviewsLowcountry Guesthouse
Guesthouse in Hanahan
4.99 out of 5 average rating, 80 reviewsThe Violet Villa w/ no cleaning fee
Guesthouse in Goose Creek
4.96 out of 5 average rating, 50 reviewsThe Blue Secret
Guesthouse in Charleston
4.94 out of 5 average rating, 80 reviewsSpacious 1 bedroom cottage in Avondale
Guesthouse in Charleston
5.0 out of 5 average rating, 15 reviewsGas Light Carriage House James Island
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 245 reviewsDetached Guest Suite
Guesthouse in Charleston
4.99 out of 5 average rating, 147 reviewsLarge Guesthouse with Private Dock & Marsh Views
Guesthouse in Charleston
5.0 out of 5 average rating, 220 reviewsJames Island "La Casita" Nestled btw Beach & City
Guesthouse in Charleston
4.99 out of 5 average rating, 209 reviewsRedesigned suite! 12min to city, pet-friendly
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 439 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 258 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 118 reviewsBeach, downtown, Alhambra Hall weddings so close!
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 251 reviewsUpscale Couple's Escape | Beach & Downtown CHS
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