Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.92 out of 5 average rating, 304 reviewsMother in Law in James Island Riverland Terrace
Guesthouse in Greenville
4.92 out of 5 average rating, 585 reviewsHistoric 19th Century Cabin/Guest House
Guesthouse in Townville
4.88 out of 5 average rating, 231 reviewsLisa’s Lodge
Guesthouse in Bluffton
4.98 out of 5 average rating, 358 reviewsHickory Trace Carriage House
Guesthouse in Beaufort
4.94 out of 5 average rating, 397 reviewsMeridian Rd. Guest House Walk to Restaurants/Parks
Guesthouse in Salem
4.88 out of 5 average rating, 290 reviewsMountain Edge Loft
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 220 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Guesthouse in North Charleston
4.94 out of 5 average rating, 347 reviewsCozy Park Circle, Charleston Guest House
Guest house rentals with a patio
Guesthouse in Abbeville
4.95 out of 5 average rating, 108 reviews1-bedroom guesthouse in Abbeville, SC
Guesthouse in Charleston
4.93 out of 5 average rating, 176 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Guesthouse in Fort Mill
4.94 out of 5 average rating, 137 reviewsCarriage House Suite on Lake Wylie
Guesthouse in Johns Island
4.91 out of 5 average rating, 110 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in North Charleston
5.0 out of 5 average rating, 112 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Charleston
4.98 out of 5 average rating, 125 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Charleston
4.97 out of 5 average rating, 131 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Columbia
4.95 out of 5 average rating, 149 reviewsRenovated One Bedroom Guest House by UofSC
Guest house rentals with a washer and dryer
Guesthouse in Camden
4.91 out of 5 average rating, 271 reviewsCamden Coach House Long term stay southern balance
Guesthouse in Lyman
4.99 out of 5 average rating, 124 reviewsBlue Heron Hideaway Lakeside Retreat
Guesthouse in Charleston
4.9 out of 5 average rating, 554 reviewsCute, Cozy, Charleston Cottage
Guesthouse in Summerville
4.97 out of 5 average rating, 220 reviewsTiny Oak Cottage in Historic Downtown Summerville
Guesthouse in Abbeville
4.99 out of 5 average rating, 149 reviewsModern Carriage House
Guesthouse in Westminster
4.99 out of 5 average rating, 148 reviewsLit'l Bit O' Heaven- Rocky Top Lodge
Guesthouse in Florence
4.92 out of 5 average rating, 133 reviewsMidtown Retreat - Guest House in heart of Florence
Guesthouse in Florence
4.99 out of 5 average rating, 673 reviewsBoho Private Downtown Stay Near I-95 & Hospital
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