Vacation rentals in Santee River

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Top-rated vacation rentals in Santee River

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Home in North Charleston

4.85 out of 5 average rating, 136 reviews

Walk to Playground & Dining|Game Room|Pet Friendly

SeanRating, 5 stars1 week ago

This place was great for a young family!! Especially for families with school aged children. Not only did the home provide a clean, safe, and spacious environment. It had activities in the home to engage all family members, not to mention one of the greatest playgrounds we have ever encountered located just across the street. The host was gracious and very responsive. We were very satisfied with our choice. Five stars across the board!!

Guest favorite

Home in Isle of Palms

4.93 out of 5 average rating, 100 reviews

Steps from the beach: extraordinary home and yard

ShannonRating, 5 stars4 days ago

Our stay at Melissa’s place was fantastic! She was super responsive from the beginning. We came down for the week of our wedding so we were pretty stressed, but Melissa took away some of that stress by making our stay phenomenal. The house is absolutely gorgeous, colorful and fun! It was a fantastic space for a big family and pets. Our dogs loved having a yard to play in and space for the kids to run around with. Melissa also checked in with me after we had settled in and made sure we were happy with the accommodations. The house was also clean and tidy both inside and out back. Would highly recommend this home for your next stay in the area! We will definitely be back!

Guest favorite

Townhouse in Mount Pleasant

4.84 out of 5 average rating, 106 reviews

Luxury Townhouse with Charleston Coastal Cottage Flair

AmaliaRating, 5 stars6 months ago

This Airbnb was fantastic! Perfect location, very clean and spacious, and comfy and cozy. The backyard was also really cute! Would recommend taking a short walk to the Pitt Street Bridge for pretty views of the water.

Guest favorite

Home in Isle of Palms

4.91 out of 5 average rating, 119 reviews

Amazing Location, across the st. from the beach!

ReevesRating, 5 stars1 week ago

Great location- super close to the beach. Great house for a dog- large fenced in backyard and screened porches and decks that are easily closed off to keep your pet with you and not wandering off. Isle of Palms is great and this house is super close to the grocery store and on great biking and walking trails.

Guest favorite

Villa in Isle of Palms

5 out of 5 average rating, 7 reviews

Lagoon Villa 34 - Top Floor Serenity! Near Ocean!

SherryRating, 5 stars1 month ago

Thank you so much! It was a great time even though the first few days were not great weather. Really happy to get a beach day in before we had to check out. The accommodations were amazing. Enjoyed things like sightseeing in Charleston, as well as enjoy games and just hanging out in the beautiful accommodations.

Guest favorite

Home in Summerville

4.83 out of 5 average rating, 6 reviews

Beautiful and spacious 5/3, near I95 /I 26.highway

DanetteRating, 5 stars4 months ago

Laura was a wonderful host who went above and beyond to ensure we were comfortable and had all the amenities during our stay. She was very quick to respond and ensured any issue was handled quickly. I would certainly recommend her for anyone interested to book at her house. My family and I felt at home and really enjoyed our stay! Laura is a lovely lady!

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What guests are saying

Modern Beach Home Quiet Street, Easy Walk to Beach

5 out of 5 average rating, 9 reviews4 months ago

We had a great stay at this property for our first visit to Isle of Palms! It was exactly as pictured and matched the description perfectly. It was very clean with comfortable beds and a quick one block walk to the beach. The host was so responsive and checked in on us daily. Loved the location and would stay here again in the future!

Home in Isle of Palms

What guests are saying

Old Village Coastal Charm★ by Beaches & Charleston

4.89 out of 5 average rating, 85 reviews1 week ago

My family and I stayed at Cindi and John’s while in town for a family reunion on isle of palm. The location was perfect, 15 mins to IOP and 15 mins into the city. Very comfortable, easy to park, and had all the things we needed to make our stay comfortable!

Townhouse in Mount Pleasant

What guests are saying

Blue Wave-Minutes from Downtown Charleston

4.84 out of 5 average rating, 108 reviews1 month ago

Akira’s place was exactly like it looked in the pictures, very clean, and had everything one might need. I know people make comments about the surrounding area, but everybody minds their business and we never felt unsafe. Akira was very responsive and got back to me super quick with any questions we had. She was able to accommodate an early check in as well. This is my second time staying at one of her places and I will definitely stay with her again!

Apartment in North Charleston

What guests are saying

Charleston King Suite Hot Tub Fire Place Patio 1

4.9 out of 5 average rating, 29 reviews4 months ago

Extremely comfortable beds, spotless home, tons of extra towels and linens, well stocked kitchen, excellent wifi and tvs, super great location, and very safe for a family with kids. This is the best Air bnb I have ever stayed at . 100 percent perfect stay!

Home in Ladson

What guests are saying

Relaxing Getaway Close to Everything 3BR/2.5Bath

5 out of 5 average rating, 25 reviews8 months ago

Tricia was extremely responsive and easy to work with! This condo was in the perfect location! Right across the street from the renowned Ion neighborhood with phenomenal food. 10 minutes to downtown Charleston and 10 minutes to Sullivans island beach’s! The condo was so well equipped with linens, towels, toilet paper, soap, and anything else you may need thing your stay! We will definitely be visiting again! Thank you Tricia!

Townhouse in Mount Pleasant

What guests are saying

Adorable Home With Heated Pool

5 out of 5 average rating, 24 reviews1 day ago

This is an adorable home in a sweet area of Charleston. The house was very clean and the beds and linens very comfortable. We loved the neighborhood, and walking to Bad Bunnies for coffee time and all of King Street. Courtney was one of the sweetest hosts we have met on Airbnb. Thank you!

Home in Charleston

What guests are saying

Stunning 4BR Oceanfront | Deck | W/D

4.72 out of 5 average rating, 54 reviews2 weeks ago

Host was always quick to respond. Location is perfect, walkable to restaurants and shops. House is a little dated but worth it as it was as described and view and amenities were perfect. The two levels of deck space was excellent because you could sit and enjoy view in the shade or be on the upper deck for sunshine and view. Great for a group of 6-8 people as each bedroom had their own bathroom and privacy. Bedrooms were good size with 3 of them provided access to a deck space and view of ocean. Would definitely stay again.

Home in Isle of Palms

What guests are saying

Exquisite Newly Built 2204 sq ft End Unit Townhome

5 out of 5 average rating, 8 reviews4 days ago

Nicely laid out, huge kitchen & dining space. Read out on the patio, walked up to a hidden pier area and just listened to the water from Goose Creek. Everyone we encountered said hello. Lots of dog walkers. There was a cat that visited the ground level backyard. We weren’t ‘home’ a lot due to a Navy Ceremony, but when we were, it was nice! Huge TV, comfy beds, lots of towels & nice grocery store close by. The only thing worth noting was better TP would be appreciated. But we survived. Great place, highly recommended!

Home in Hanahan

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Popular amenities for Santee River vacation rentals

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Other great vacation rentals in Santee River

Guest favorite

Home in Summerton

4.83 out of 5 average rating, 108 reviews

Perfect family vacation retreat at Lake Marion, SC

MichaelRating, 5 stars1 week ago

We had a great weekend! The house was great as well as the outdoors. We enjoyed fishing and having the private dock. We also enjoyed the fire pit. Andrea was an excellent host and we strongly recommend this listing. Thanks again Andrea!

Top guest favorite

Home in Summerton

5 out of 5 average rating, 15 reviews

Almost Heaven on Lake Marion, SC

GlendaRating, 5 stars4 days ago

My family had an amazing stay for spring break! The pictures really do not do this place justice. The home’s layout is spacious and the kitchen is stocked with all the necessities. The back porch is huge and looks onto the lake. The private beach area is perfect for laying out and there are plenty of chairs. We used the dock for fishing and were able to rent a pontoon boat that we tied up to the dock for easy access. Audrey was very responsive and helpful with any questions that we had. I would definitely rent this place again!

Top guest favorite

Home in Manning

5 out of 5 average rating, 28 reviews

Lakeside Hideaway

KatrinaRating, 5 stars1 month ago

Heather is an amazing host. She made us feel as if we were home. It was so comfortable, and cozy. I would absolutely highly recommend staying here. We will definitely come back, and stay here again. Thank you for everything Heather.

Superhost

Home in Summerville

4.69 out of 5 average rating, 103 reviews

Low Country Living by Low Country BNB

ErinRating, 5 stars3 weeks ago

I can't say enough good things about Iris and this place! They were extremely kind and helpful. Would recommend staying with them anytime you are in the area! I know we will be!

Superhost

Condo in Isle of Palms

4.82 out of 5 average rating, 17 reviews

#107 Cozy Corner, 2br/2ba

JeanetteRating, 5 stars13 months ago

My expectations were surpassed! Loved staying here for the few days we were in Isle of Palms. It is the perfect walking distance from the beach and has everything you’ll need for your stay! It did take us a couple tries to understand the lock but we are thankful for that note so we didn’t freak out! Lol thank you!

Condo in Isle of Palms

4.92 out of 5 average rating, 176 reviews

Ocean Breeze Villa

PattyRating, 5 stars1 week ago

Great location…. Loved hearing the ocean. Donna was quick to respond on any issues. Great place to stay!

Top guest favorite

Home in North Charleston

5 out of 5 average rating, 54 reviews

Pool | Charleston | Near Airport, Downtown & Beach

RaquelRating, 5 stars4 days ago

We stayed here for my friend’s bachelorette and had the best time! The place was super clean and had everything we needed. The host was responsive and made everything easy. Would definitely recommend for a fun and relaxing getaway!

Superhost

Apartment in Isle of Palms

4.74 out of 5 average rating, 199 reviews

Cozy Beachside Retreat

TamalaRating, 5 stars2 weeks ago

Very short walk to the beach. Located in Wild Dunes, this condo unit is at the far end of the island, and we had tons of space on the beach. You also get access to the pool and golf course. Uber/Lyft readily available for transportation to downtown or across the bridge to Charleston. The condo itself is basic so if you need extra towels, pillows, and blankets, bring them. Overall a great value for the weekend stay.

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Vacation rentals in Santee River

Top-rated vacation rentals in Santee River

Russ's Cottage: Old Village + Walk to Restaurants!

End Unit 2 Bedroom Oceanfront Condo with Pool

Modern Beach Home Quiet Street, Easy Walk to Beach

Old Village Coastal Charm★ by Beaches & Charleston

Blue Wave-Minutes from Downtown Charleston

Charleston King Suite Hot Tub Fire Place Patio 1

Quiet 4BR | Pool | W/D | Walk to Beach

Relaxing Getaway Close to Everything 3BR/2.5Bath

Adorable Home With Heated Pool

Stunning 4BR Oceanfront | Deck | W/D

Exquisite Newly Built 2204 sq ft End Unit Townhome

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