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Boutique hotel vacation rentals in Missouri

Find and book unique boutique hotel rentals on Airbnb

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Popular amenities for Missouri boutique hotel rentals

Family-friendly boutique hotels rentals

Guest favorite
Hotel room in St. Louis
4.87 out of 5 average rating, 713 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

ChristopherRating, 5 stars3 weeks ago
We enjoyed our stay and would recommend for those who are staying in St. Louis or plan to. Be sure to plan ahead and secure one of the parking places, as it was difficult to find parking spot on the street.
Guest favorite
Hotel room in Hermann
4.95 out of 5 average rating, 44 reviews

Hermann Crown's New Pet Friendly Shepherd's Suite

CassieRating, 5 stars5 days ago
The place was just a described. We liked the location was walkable and that we had access to the hotel amenities, but felt like we had a private space.
Guest favorite
Hotel room in Hermann
4.82 out of 5 average rating, 45 reviews

Hermann Crown's Victorian Suite, Tons of Amenities

ShannaRating, 5 stars3 months ago
Very quaint boutique. Room was perfect. Everyone was very friendly and helpful with any questions we had. We loved the shuttle service to and from the wineries. The downstairs bar and live music was the perfect way to end the evening. We will definitely be back.
Hotel room in La Plata
4.73 out of 5 average rating, 11 reviews

Depot Inn & Suites - Luxury Themed Suites

MichaelRating, 5 stars2 months ago
This was a great place for a relaxing little Valentine’s Day getaway for my wife and I. Our lives are very busy and stressful and it was nice to be here and relax in the jetted tub while watching TV and then play board games and sleep.
Guest favorite
Hotel room in St. Louis
4.87 out of 5 average rating, 631 reviews

Evergreen Room Queen Bed at BnB in CWE

NettaRating, 5 stars1 month ago
Not only was the stay perfect my partner left his cellphone at the Airbnb and without hesitation they shipped his phone out for us very kind and caring people !
Guest favorite
Hotel room in St. Louis
4.85 out of 5 average rating, 753 reviews

The Maple Room Queen Bed at BnB in CWE!

MarcusRating, 5 stars3 weeks ago
Awesome accommodation and great environment and customer support.
Hotel room in Lexington
4.84 out of 5 average rating, 43 reviews

Wentworth Mansion Suite 1

AlexisRating, 5 stars29 months ago
We look forward to every stay in Room 6! We love Terrie’s bright smile and recommendations to local events. We can’t wait to return to Lexington!
Superhost
Hotel room in Hermann
4.8 out of 5 average rating, 30 reviews

Hermann Crown's Presidents Suite, 3 Beds & 2 Baths

ChristinaRating, 5 stars2 months ago
My girlfriends and I stayed here to celebrate a birthday, and it was perfect! Plenty of space for 8 of us! There is a restaurant/bar with live music right underneath the hotel, and you can walk across the street to the Piano Bar, and have a blast! Bring some tip money to hear your favorite requests 💃🏽🎶 There are also cute stores and shops within walking distance.

Boutique hotels rentals with a patio

Superhost
Hotel room in Osceola
5 out of 5 average rating, 10 reviews

Historic Commercial Hotel(1868)Karolyn Grimes Room

KevinRating, 5 stars9 months ago
This is a neat little spot. Definitely felt like an old west hotel in terms of decor. Simple room and to the point. Comfy bed. I know this town since I'm from the area, but there's good printed info in the room for the local spots to check out. On the town square, so great if you're visiting for a car show! Easy parking (I was in a Uhaul).
Guest favorite
Hotel room in Versailles
4.9 out of 5 average rating, 40 reviews

Cozy hotel secluded in the woods 4 Full size beds

KelseyRating, 5 stars5 months ago
Great stay for one night weekend get away! Very clean and just very proactive and responsive to us! Able to check in early and fit our needs exactly!
Guest favorite
Hotel room in Saint Charles
5 out of 5 average rating, 14 reviews

#4 – Penny Farthing Le Velo Inn

PeterRating, 5 stars6 days ago
This was a great place. My wife and I enjoyed it very much. We enjoyed the sitting area in the back and walking down the street to the little shops and restaurants.
Guest favorite
Hotel room in St. Louis
4.97 out of 5 average rating, 30 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

LatonyaRating, 5 stars2 months ago
It was worth it and then some Jess was amazing. Her mother was amazing. Very helpful. I hope to come back. Matter fact I will be coming back. I think I’m gonna celebrate my own birthday there.
Top guest favorite
Hotel room in St. Louis
5 out of 5 average rating, 11 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

AkshayRating, 5 stars2 months ago
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.
Hotel room in St. Louis
4.73 out of 5 average rating, 56 reviews

The West End by Cortex, Forest Park, BJC & Zoo

ShellieRating, 5 stars4 weeks ago
Was a nice place to stay

Destinations to explore