Vacation rentals in Darlington County

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Top-rated vacation rentals in Darlington County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Florence

4.88 out of 5 average rating, 482 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Guest favorite

Camper/RV in Hartsville

4.85 out of 5 average rating, 20 reviews

Lakeside RV

Check it out the lake through the bedroom window or walk outside and take a swim. This home has a queen bed in the master, twin in the spare bedroom and a fold out couch. Each bedroom has a smart tv, living room has one as well. There are two boat landings within a half mile if you want to bring a boat. About 10 minutes from Hartsville, and conveniently located close to HB Robinson Power Plant, Sonoco Paper, and much more. There are 2 other Airbnbs on property that may provide neighbors

Guest favorite

Apartment in Florence

4.93 out of 5 average rating, 15 reviews

“Cozy Escape | Relax & Recharge”

Discover your perfect getaway in this beautifully furnished 2-bedroom, 1.5-bathroom retreat. Featuring sleek, updated appliances and the convenience of an in-unit washer and dryer, this space blends style and comfort effortlessly. Nestled in a prime, sought-after neighborhood, you’ll enjoy both tranquility and easy access to local hotspots. Conveniently located near Magnolia Mall. A perfect blend of shopping, dining. Book your stay and experience the best of home living with a touch of luxury!

Top guest favorite

Home in Hartsville

5 out of 5 average rating, 104 reviews

Manchester Place

Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Top guest favorite

Farm stay in Timmonsville

4.95 out of 5 average rating, 621 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Guest favorite

Home in Hartsville

4.84 out of 5 average rating, 120 reviews

Quaint 2BR home w access to Black Creek & downtown

Our freshly renovated home sits in a family-oriented neighborhood only a mile from downtown Hartsville and Kalmia Gardens and includes access to Black Creek. This 600 sf home features 2 bedrooms, 1 bath, a full kitchen, washer and dryer and an open living area. Digital antenna reception for smart-tv and high speed wi-fi internet. Small dogs will be considered for stays on a case-by-case basis. Pet stays require prior approval from the hosts and will involve additional fees.

Guest favorite

Guesthouse in Florence

4.93 out of 5 average rating, 822 reviews

The Cottage by the Pool: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

Guest favorite

Apartment in Hartsville

5 out of 5 average rating, 15 reviews

Charming Southern Comfort Getaway

This is a very inviting apartment that is newly renovated. Safe and peaceful neighborhood. Includes full kitchen, keurig coffee pot, microwave, all linens, Queen sofa bed, close to a lot of amenities. Delivery service available through WeGo Delivery. Great location. *2 miles from Robinson Nuclear Plant *2 miles from Carolina Pines/MUSC *37 miles from Walmart Distribution Pageland *6 miles from Coker College *6 miles from Sonoco NO SMOKING/NO PETS

Top guest favorite

Bungalow in Florence

4.99 out of 5 average rating, 89 reviews

Quaint Bungalow in Historic Downtown Florence

You are invited to experience a quiet and relaxing time at Elley’s Bungalow. This home is completely renovated and fully furnished. Surrounded by friendly neighbors extending southern hospitality. Excellent property for nurses, per diem workers, or professionals on a short term assignment in Florence or surrounding areas. Located minutes away from McLeod Regional Medical Center, MUSC Florence, Francis Marion University, and Downtown Florence.

Top guest favorite

Home in Florence County

5 out of 5 average rating, 113 reviews

Highway Oasis and Myrtle Beach

Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.

Guest favorite

Guesthouse in Florence

4.92 out of 5 average rating, 196 reviews

Midtown Retreat - Guest House in heart of Florence

A private, relaxing place to stay right in the middle of town. Conveniently located close to all Florence has to offer, this 1-bedroom guest house is nestled among the trees behind the main house. Located in a beautiful, quiet neighborhood, yet within a few minutes to restaurants, grocery stores, fitness centers, McLeod and MUSC Medical Centers, and more.

Guest favorite

Apartment in Florence

4.81 out of 5 average rating, 42 reviews

Home Away from Home! 1 Br & 1 Bath Apt. with Porch

Need a place for a couple of weeks or a month? Enjoy a stylish experience at this centrally-located place with washer/dryer and outdoor private space for your quick visit or extended stay. Comfortable queen bed and fan to help you enjoy a good nights rest.

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What guests are saying

Cozy Log Cabin retreat on a farm.

5 out of 5 average rating, 61 reviews1 week ago

We were made to feel like royalty. The Prescott Farm is a jewel in South Carolina. The log cabin is perfect in every single way. We also were totally spoiled with fresh eggs, juice and muffins. This trip was to relax and regroup with family. Thank you Prescotts for the lovely visit!

Cabin in Hartsville

What guests are saying

Peaceful Pine Stays/ 5 min. from Mcleod hospital

5 out of 5 average rating, 15 reviews4 days ago

Donieka’s Peaceful Pines was the ideal AirBnB for our trip to Florence. We were in town for a week visiting family. Peaceful Pines was “home away from home.” Donieka stocked every room with essentials plus amenities that made our stay that much more comfortable. The cookware and appliances are NOT the discarded goods of a primary home. They are in excellent condition along with the quality of the linens and larger appliances. The beds are very comfortable and the bathrooms have been beautifully renovated and are sparklingly clean. I was able to work remotely in comfort and we all slept restfully.

Home in Florence

What guests are saying

Turtle Cove | 3-bdrm in Dwntwn H-Ville

4.9 out of 5 average rating, 10 reviews1 week ago

Loved this spot -- clean, good space, nice touches like host providing coffee, shampoo and colorful plush throw blankets. This is super close to Sunoco and Coker University, and an easy walk to downtown Hartsville. We didn't use our car during our weekend stay. Also loved that it's dog-friendly, including a fenced back yard. Craig was responsive and accommodating; when we realized our brunch plans would run past the 11 a.m. checkout he quickly authorized us to take more time. We definitely plan to book this again.

Home in Hartsville

What guests are saying

Bungalow near downtown & parks

4.93 out of 5 average rating, 14 reviews2 weeks ago

We stayed there to be closer to the Darlington NASCAR race. Close to the track, restaurants and grocery store. House was clean and tidy. We enjoyed hanging out on the back porch and the neighbors were the nicest people and cooked us dinner one night. Sandi was responsive and extremely nice. We will definitely consider her home again.

Home in Florence

What guests are saying

Modern 3B/2Ba Condo- Sleeps 6, near Civic Center

4.94 out of 5 average rating, 72 reviews2 weeks ago

We had a wonderful time. Parking spots are marked clearly, and the directions for how to get in were easy to follow. Once inside the place was exactly as described. The beds were all comfortable, had plenty of space for our group of 3, and I will definitely stay here again if I make my way back to Florence. We ate at some of the recommended Restaurants. Town Hall was amazing (try the swordfish.) Thanks for Hosting Us!!!!

Apartment in Florence

What guests are saying

2B/1.5BA townhouse in florence

5 out of 5 average rating, 17 reviews6 months ago

We were in town for a tennis tournament at the Florence tennis center. This place was perfect for our needs for the long weekend. Just a couple miles from the courts, it allowed us a place to have meals and found it superior to staying in a hotel which is what we’ve done at previous tournaments. Wempy was super responsive, the place was clean and updated, and we’ll be back when in Florence for the next one :)

Townhouse in Florence