Villa vacation rentals in Panama
Find and book unique villas on Airbnb
Top-rated villa rentals in Panama
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama villa rentals
Villa rentals with a pool
Villa in Lagartero
5.0 out of 5 average rating, 12 reviewsPrivate Villa with private pool, in Santa Catalina
Villa in PA
4.81 out of 5 average rating, 72 reviewsVilla Estrella in Playa Venao
Villa in Río Grande
4.94 out of 5 average rating, 51 reviewsCheerful 3 bedroom countryside Villa with pool.
Villa in Bocas del Toro Province
4.88 out of 5 average rating, 43 reviewsLuxury Villa Rainforest Estate swim pond.
Villa in Playa Venao
4.88 out of 5 average rating, 16 reviewsVilla Best Located in Blue | With Private Pool
Villa in Playa Venao
4.92 out of 5 average rating, 24 reviewsVilla La Piragua : 3BR Surfside Retreat : 5-7G
Villa in Las Lajas
4.62 out of 5 average rating, 77 reviewsCORONADO VILLA VICTORIA
Villa in Contadora Island
4.88 out of 5 average rating, 8 reviewsCheerful 2-bedroom villa with shared pool
Private villa rentals
Villa in Saboga
5.0 out of 5 average rating, 7 reviewsSaboga: El Remanso Beachfront Entire Upper Level
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Villa in Bocas del Toro
5.0 out of 5 average rating, 16 reviewsCasa de Mono Luxury Open Air 3 Bedroom Apartment
Villa in Bajo Boquete
4.94 out of 5 average rating, 64 reviewsSpacious Villa on a Coffee Farm 5 mins from town!
Villa in Anton Valley
4.95 out of 5 average rating, 39 reviewsQuinta El Forest
Villa in Santiago
4.89 out of 5 average rating, 38 reviewsLes Terrasses de Playa Morrillo
Villa in Casamar
5.0 out of 5 average rating, 3 reviewsVilla La Valenciana by AcoModo @Casamar
Villa in Boca Chica
4.95 out of 5 average rating, 81 reviewsSand Dollar Villa by the sea at Boca Chica Panama
Luxury villa rentals
Villa in Buenaventura, El Chirú
4.85 out of 5 average rating, 47 reviewsLake House | Pool | King Beds | Next to Beach Club
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Villa in Panamá
5.0 out of 5 average rating, 34 reviewsBreathtaking Views Mansion w/King Beds
Villa in Punta Chame
4.92 out of 5 average rating, 13 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Villa in Las Escobas del Venado
4.95 out of 5 average rating, 21 reviewsBreathtaking Ocean Villa. Casa de Vida
Villa in Río Hato
4.91 out of 5 average rating, 22 reviewsSecluded Villa in Buenaventura Golf and Resort
Villa in Panamá
4.73 out of 5 average rating, 11 reviewsIncredible Hacienda with ocean and river View
Destinations to explore
- Loft rentals Panama
- Rentals with a home theater Panama
- House rentals Panama
- Vacation home rentals Panama
- Fitness-friendly rentals Panama
- Smoking-friendly rentals Panama
- Apartment rentals Panama
- Cottage rentals Panama
- Rentals with pools Panama
- Beach condo rentals Panama
- Chalet rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Rentals with a patio Panama
- Kid-friendly rentals Panama
- Bungalow rentals Panama
- Pet-friendly rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Family-friendly rentals Panama
- Waterfront rentals Panama
- Monthly Rentals Panama
- Farmstay rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Nature eco lodge rentals Panama
- Beach house rentals Panama
- Rentals with a sauna Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Rentals with beach access Panama
- Rentals with breakfast Panama
- Rentals with an accessible height bed Panama
- Tiny house rentals Panama
- Treehouse rentals Panama
- Island rentals Panama
- Boutique hotel rentals Panama
- Townhouse rentals Panama
- Guesthouse rentals Panama
- Rentals with a washer and dryer Panama
- Rentals with a fire pit Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Hotel rentals Panama
- Condo rentals Panama
- Boat rentals Panama
- Bed and breakfasts Panama
- Rentals with a fireplace Panama
- Rentals with a hot tub Panama
- Wheelchair accessible rentals Panama
- Rentals with lake access Panama
- Villa rentals Panama City
- Villa rentals Playa Coronado
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes